J Korean Orthop Assoc.  1978 Jun;13(2):219-224. 10.4055/jkoa.1978.13.2.219.

Squamous Cell Carcinoma Arising From Chronic Osteomyelitis: A Report of One Case

• Bae DK
• Kim MH
• Choi JS
• Hahn MS

• KMID: 2460386
• DOI: http://doi.org/10.4055/jkoa.1978.13.2.219

Abstract

Squamous cell carcinoma is a rare complication of chronic osteomyelitis. Squamous cell carcinoma of extremity campromises approximately 1 to 2% of all squamous cell carcinoma and of these 2.5 to 4.5% are secondary to chronic osteomyelitis. Biopsy of squamous cell carcinoma, which arises in the proliferating edge of the cutaneous ulcer and invades the bone, should include tissues from all portion of sites of ulcer including bone marrow spaces. But histological diagnosis may be difficult becasue of preexisiting and coexisisting metaplasia and pseudo-epitheliomatous hyperplasia. With prompt and aggressive surgical treatment, the prognosis for patient with squamous cell carcinoma secodary to chronic osteomyelitis is good. Routine regional lymphadenectomy at site of amputation seems unnecessary. This case report represets an unusual bone marrow involvement of squamous cell carcinoma which was complicated by femur fracture.

MeSH Terms

Amputation
Biopsy
Bone Marrow
Carcinoma, Squamous Cell*
Diagnosis
Epithelial Cells*
Extremities
Femur
Humans
Hyperplasia
Lymph Node Excision
Metaplasia
Osteomyelitis*
Prognosis
Ulcer