Korean J Pathol.  2009 Aug;43(4):306-311.

eNOS Gene Polymorphisms in Perinatal Hypoxic-Ischemic Encephalopathy

Affiliations
  • 1Institute of Medical Science, Dankook University College of Medicine, Cheonan, Korea.
  • 2Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea. ychang@dankook.ac.kr
  • 3Department of Anatomy, Dankook University College of Medicine, Cheonan, Korea.

Abstract

BACKGROUND
In perinatal hypoxic-ischemic encephalopathy (HIE), cerebral blood flow is impaired and the activity of nitric oxide systhase (NOS) is markedly increased. For the association with the development of a stroke, the endothelial NOS (eNOS) polymorphisms are well-known. METHODS: Three clinically relevant polymorphisms of the eNOS gene were determined in 37 term/near-term infants with perinatal HIE (HIE group) and 54 normal term newborn infants without any perinatal problems (control group) using a polymerase chain reaction with or without restriction fragment enzyme digestion. The differences in the genotype, allele, and haplotype frequencies were evaluated between the groups. RESULTS: The analysis of the allele frequencies showed that the G allele of Glu298Asp was more frequent in the HIE group than in the controls. The comparisons between the controls and each subgroups with complications that occurred with HIE showed that the TC genotype and C allele of T(-786)C were more common in patients with persistent pulmonary hypertension of the newborn (PPHN) than in the controls. The frequency of the A b T haplotype was lower in the HIE patients than in the controls. CONCLUSIONS: The G allele of Glu298Asp was associated with perinatal HIE, while the TC genotype and C allele of T(-786)C were associated with PPHN.

Keyword

Nitric oxide; Endothelial NOS (eNOS); Genetic polymorphism; Hypoxic-ischemic encephalopathy; Newborn; Infant; Persistent pulmonary hypertension of the newborn (PPHN)

MeSH Terms

Alleles
Cerebrovascular Circulation
Digestion
Gene Frequency
Genotype
Haplotypes
Humans
Hypertension, Pulmonary
Hypoxia-Ischemia, Brain*
Infant
Infant, Newborn
Nitric Oxide
Polymerase Chain Reaction
Polymorphism, Genetic
Stroke
Nitric Oxide
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