Korean J Gastroenterol.  2019 Sep;74(3):130-136. 10.4166/kjg.2019.74.3.130.

Hepatitis E Virus: Epidemiology, Diagnosis, and Management

• Heo NY

• KMID: 2458692
• DOI: http://doi.org/10.4166/kjg.2019.74.3.130

Abstract

The HEV is a known cause of water-borne outbreaks of acute non-A non-B hepatitis in developing countries, which affects young people and may result in high mortality in pregnant women. In recent decades, however, HEV genotypes 3 and 4 have been known as a cause of sporadic zoonotic infections in older males from swine HEV worldwide. Most acute HEV infections are self-limited. On the other hand, in immunosuppressed patients, including solid organ transplant recipients, chronic HEV infections may exist and progress to liver cirrhosis or decompensation. Therefore, physicians need to recognize HEV as a major pathogen for acute and chronic hepatitis of unknown causes and investigate this disease.

Keyword

Hepatitis E; Waterborne diseases; Zoonoses; Genotype

MeSH Terms

Developing Countries
Diagnosis*
Disease Outbreaks
Female
Genotype
Hand
Hepatitis E virus*
Hepatitis E*
Hepatitis*
Hepatitis, Chronic
Humans
Liver Cirrhosis
Male
Mortality
Pregnant Women
Swine
Transplants
Waterborne Diseases
Zoonoses

Figure

• 

  Fig. 1 Transmission route of hepatitis E virus genotype 1 and 2 (A), and genotype 3 and 4 (B).

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