J Lipid Atheroscler.  2019 Sep;8(2):252-257. 10.12997/jla.2019.8.2.252.

Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations

• Sull JW
• Kim S
• Jee SH

• KMID: 2458390
• DOI: http://doi.org/10.12997/jla.2019.8.2.252

Abstract

OBJECTIVES
The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women.
METHODS
We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304).
RESULTS
We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: −2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39-2.85) compared with men (OR, 1.33; 95% CI, 1.10-1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86-12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m², individuals with a CG/GG genotype and BMI ≥25.69 kg/m² had an OR (95% CI) of 2.61 (1.97-3.47).
CONCLUSIONS
These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.

Keyword

Cholesterol ester transfer proteins; HDL cholesterol; Physical activity; Genetic polymorphisms

MeSH Terms

Alleles
Body Mass Index
Cholesterol
Cholesterol Ester Transfer Proteins
Cholesterol, HDL
Female
Genotype
Humans
Korea
Lipoproteins
Male
Motor Activity
Obesity*
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Cholesterol
Cholesterol Ester Transfer Proteins
Cholesterol, HDL
Lipoproteins

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