J Korean Clin Nurs Res.  2019 Aug;25(2):170-178. 10.22650/JKCNR.2019.25.2.170.

Impact of Depression on Medication Adherence of Patients with Systemic Lupus Erythematosus: Focusing on Mediating Effect of Self-Efficacy and Belief about Medication

• Lee SJ
• Ju HO

• KMID: 2457428
• DOI: http://doi.org/10.22650/JKCNR.2019.25.2.170

Abstract

PURPOSE
The purpose of this study was to determine the mediating effects of self-efficacy and the belief about medication on the association between depression and medication adherence in patients with systemic lupus erythematosus.
METHODS
128 patients aged ≥19 years, who were regular outpatients or admitted patients diagnosed with systemic lupus erythematosus at a tertiary hospital in B city, participated in this study. Data were collected by using a self-administered questionnaire. Testing of mediating effects was analyzed by a parallel redundant mediated model using the PROCESS macro for SPSS version 3.3.
RESULTS
They scored an average of 16.71±11.13 for depression, 694.14±170.68 for self-efficacy, 3.05±4.60 for the belief about medication, and 90.14±15.37 for medication adherence. The direct effect of depression on medication adherence was not statistically significant, but the indirect effects of depression mediated with self-efficacy and belief about medication were statistically significant.
CONCLUSION
It is necessary to develop and apply a nursing intervention program that can not only relieve depression but also promote self-efficacy and the belief about medication with the objective of improving medication adherence among patients with systemic lupus erythematosus.

Keyword

Systemic Lupus Erythematosus; Depression; Self-Efficacy; Perception; Medication Adherence

MeSH Terms

Depression*
Humans
Lupus Erythematosus, Systemic*
Medication Adherence*
Negotiating*
Nursing
Outpatients
Tertiary Care Centers