J Gynecol Oncol.  2019 Mar;30(2):e27. 10.3802/jgo.2019.30.e27.

Minimally invasive surgery improves short-term outcomes of nerve-sparing radical hysterectomy in patients with cervical cancer: a propensity-matched analysis with open abdominal surgery

• Bogani G
• Rossetti D
• Ditto A
• Martinelli F
• Chiappa V
• Leone C
• Leone Roberti Maggiore U
• Lorusso D
• Raspagliesi F

• KMID: 2457139
• DOI: http://doi.org/10.3802/jgo.2019.30.e27

Abstract

OBJECTIVES
Nerve-sparing radical hysterectomy has been implemented in order to reduce pelvic floor dysfunctions in women undergoing radical surgery for cervical cancer. Here, we aimed to investigate if the adoption of laparoscopic surgery impacts on patients' outcomes.
METHODS
Data of consecutive patients affected by cervical cancer who had laparoscopic nerve-sparing radical hysterectomy were matched 1:1 with an historical cohort of patients undergoing open procedure. A propensity-score matched algorithm was applied.
RESULTS
Thirty-five patients' pairs (70 patients: 35 undergoing laparoscopic vs. 35 undergoing open abdominal nerve-sparing radical hysterectomy) were included. Demographic and baseline oncologic characteristics were balanced between groups. Patients undergoing laparoscopic surgery had similar operative time than patients undergoing open abdominal procedures (249 [±91.5] vs. 223 [±65.0] minutes; p=0.066). Laparoscopic approach correlated with lower blood loss (30.5 [±11.0] vs. 190 [90.4] mL; p < 0.001) and shorter hospital stay (3.2 [±1.2] vs. 5.4 [2.0] days; p=0.023). Patients undergoing laparoscopy experienced a lower 30-day pelvic floor dysfunction rate than patients having open surgery. Moreover, they experienced shorter recovery of bladder function than patients having open procedures (median, 7 vs. 9 days; p=0.004, log-rank test).
CONCLUSIONS
Laparoscopic approach resulted in a faster recovery of bladder function in comparison to open surgery for patients undergoing nerve-sparing radical hysterectomy.

Keyword

Uterine Cervical Neoplasms; Hysterectomy; Urination Disorders; Laparoscopy

MeSH Terms

Cohort Studies
Female
Humans
Hysterectomy*
Laparoscopy
Length of Stay
Minimally Invasive Surgical Procedures*
Operative Time
Pelvic Floor
Urinary Bladder
Urination Disorders
Uterine Cervical Neoplasms*