Ann Dermatol.  2019 Aug;31(Suppl):S64-S65. 10.5021/ad.2019.31.S.S64.

Annular Elastolytic Giant Cell Granuloma: Chronic Heat Exposure, an Underestimated Factor

• Ahn GR
• Jeong GJ
• Han HS
• Kwon HJ
• Li K
• Seo SJ

• KMID: 2456683
• DOI: http://doi.org/10.5021/ad.2019.31.S.S64

Abstract

No abstract available.

MeSH Terms

Giant Cells*
Granuloma, Giant Cell*
Hot Temperature*

Figure

• 

  Fig. 1 (A) Clinical image of multiple annular lesions during initial visit. The brownish-red, annular shaped plaques with a slightly elevated border and shiny atrophic center. (B) Progressive lesions despite treatment with steroids and ultraviolet A therapy.

• 

  Fig. 2 (A) Skin biopsy specimen showing dermal granulomatous infiltrates of histiocytes with multinucleated giant cells (H&E, ×100). (B) Elastin stain showed fragmented elastin fibers and elastophagocytosis by giant cells (red arrowhead). The amount of elastic fiber is reduced around the granulomatous infiltrations (Verhoeff-Van Gieson stain, ×200).

Reference

1. Chen WT, Hsiao PF, Wu YH. Spectrum and clinical variants of giant cell elastolytic granuloma. Int J Dermatol. 2017; 56:738–745.

2. El-Khoury J, Kurban M, Abbas O. Elastophagocytosis: underlying mechanisms and associated cutaneous entities. J Am Acad Dermatol. 2014; 70:934–944.

3. Zacharias I, Nagy G, Orban I. [O'Brien's actinic granuloma]. Ann Dermatol Venereol. 1992; 119:137–138.

4. Rasmussen DM, Wakim KG, Winkelmann RK. Isotonic and isometric thermal contraction of human dermis. II. Age-related changes. J Invest Dermatol. 1964; 43:341–348.

5. Fujimoto N, Akagi A, Tajima S. Expression of 67-kDa elastin receptor in annular elastolytic giant cell granuloma: elastin peptides induce monocyte-derived dendritic cells or macrophages to form granuloma in vitro. Exp Dermatol. 2004; 13:179–184.