Ann Dermatol.  2019 Aug;31(Suppl):S17-S19. 10.5021/ad.2019.31.S.S17.

The face of CD4⁺ Hydroa Vacciniforme-Like Lymphoproliferative Diseases: The Shadow of Systemic T-Cell Lymphoma

• Kim YJ
• Choi ME
• Lee WJ
• Chang SE
• Choi JH
• Lee MW

• KMID: 2456664
• DOI: http://doi.org/10.5021/ad.2019.31.S.S17

Abstract

No abstract available.

MeSH Terms

Lymphoma, T-Cell*
T-Lymphocytes*

Figure

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  Fig. 1 (A~C) Multiple brownish papules and crusts are presented on the nose and left temple (A) forehead (B) and scalp (C) consistent with hydroa vacciniform-like eruptions.

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  Fig. 2 (A, B) Skin biopsy showed scattered small- to medium-sized lymphoid cells with epidermal erosion, consistent with hydroa vacciniforme-like lymphoproliferative disorders (H&E: A, ×40; B, ×200). (C, D) Immunohistochemical staining showed positive reactivity for cytoplasmic CD4 (C) and negative reactivity for CD8 (D) (C, D, ×100). (E, F) Lymph node biopsy showed polymorphic diffuse infiltration of small- to medium-sized neoplastic cells, consistent with systemic Epstein-Barr virus (EBV+) T-cell lymphoma (H&E: E, ×100; F, ×400). (G~I) Immunohistochemical staining showed positive reactivity for cytoplasmic CD4 (G) (×200) and CD8 (H) (×100). These cells were also positively reactive in EBV in situ hybridization (I) (×200).

Reference

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