Perinatology.  2019 Jun;30(2):93-98. 10.14734/PN.2019.30.2.93.

Impact of Rotavirus Infection on Neonatal Hyperbilirubinemia

• Hong M
• Lee JH

• KMID: 2453044
• DOI: http://doi.org/10.14734/PN.2019.30.2.93

Abstract

OBJECTIVE
Rotavirus (RV) infection is a common health issue in neonatal wards. Clinical outcomes include diarrhea, fever, and poor appetite. We aimed to assess the impact of RV infection on aggravation of neonatal hyperbilirubinemia and on the bilirubin response to phototherapy.
METHODS
We analyzed the clinical data of 101 newborns with jaundice admitted to a neonatal ward from 2009 to 2017. Patients were divided into RV-positive and RV-negative groups, according to the RV antigen in stool samples. Statistical analyses were used to assess the RV impact on neonatal jaundice.
RESULTS
Fifty newborns (49.5%) had RV infection. No significant differences were found between the two groups concerning mean gestational age, birthweight, age at admission, postnatal weight loss, blood urea nitrogen, base excess, and bilirubin values at admission and duration of phototherapy. The frequency of stool pass and the hospitalization period were significantly higher in the RV-positive group (P=0.002 and P=0.009, respectively). The lower the gestational age, the greater the severe jaundice (odds ratio, 0.713; P=0.028).
CONCLUSION
The incidence of RV infection was surprisingly high in newborns with jaundice, having a significant impact on hospitalization time, but not on hyperbilirubinemia severity and phototherapy duration. Rotavirus is highly contagious therefore, screening tests for RV infection should be included as part of the evaluation of jaundiced infants admitted to neonatal ward and prevent transmission.

Keyword

Neonate; Jaundice; Rotavirus; Phototherapy

MeSH Terms

Appetite
Bilirubin
Blood Urea Nitrogen
Diarrhea
Fever
Gestational Age
Hospitalization
Humans
Hyperbilirubinemia
Hyperbilirubinemia, Neonatal*
Incidence
Infant
Infant, Newborn
Jaundice
Jaundice, Neonatal
Mass Screening
Phototherapy
Rotavirus Infections*
Rotavirus*
Weight Loss
Bilirubin

Reference

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