Yonsei Med J.  2019 Aug;60(8):791-795. 10.3349/ymj.2019.60.8.791.

Uterine Leiomyoma Is Associated with Female Sexual Dysfunction in Postmenopausal Women

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea. smleemd@hanmail.net
  • 2Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • 3Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. skkim@snubh.org
  • 5Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
  • 6Health Promotion Center, Seoul National University Hospital, Seoul, Korea.
  • 7Department of Family Medicine, Asan Medical Center, Seoul, Korea.
  • 8Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

PURPOSE
To determine the relationship between uterine leiomyoma and female sexual dysfunction (FSD) among premenopausal and postmenopausal women.
MATERIALS AND METHODS
The study population consisted of consecutive women who underwent gynecologic screening tests, including transvaginal ultrasound, and completed the questionnaires on FSD. A total of 841 women were included from January 2010 to December 2011. FSD was defined as Female Sexual Function Index (FSFI) ≤26.55. The relationship between uterine leiomyoma and FSD were compared according to menopausal status.
RESULTS
In premenopausal group (n=564), there were no differences in the frequency of FSD (55.0% vs. 58.8%, p=0.387) and total FSFI score. However, in postmenopausal group (n=277), women with uterine leiomyoma had a lower frequency of FSD than those without uterine leiomyoma (71.3% vs. 86.4%, p=0.003). This relationship between uterine leiomyoma and lower frequency of FSD in postmenopausal women remained significant after adjusting for confounding variables.
CONCLUSION
The relationship between uterine leiomyoma and FSD is different depending on the menopausal status.

Keyword

Sexual dysfunction; sexual behavior; leiomyoma; menopause; dyspareunia

MeSH Terms

Confounding Factors (Epidemiology)
Dyspareunia
Female*
Humans
Leiomyoma*
Mass Screening
Menopause
Sexual Behavior
Ultrasonography

Reference

1. Srivastava R, Thakar R, Sultan A. Female sexual dysfunction in obstetrics and gynecology. Obstet Gynecol Surv. 2008; 63:527–537. PMID: 18631409.
Article
2. Sarrel PM. Sexuality and menopause. Obstet Gynecol. 1990; 75(4 Suppl):26S–30S. PMID: 2179787.
Article
3. Kim YH, Kim SM, Kim JJ, Cho IS, Jeon MJ. Does metabolic syndrome impair sexual function in middle- to old-aged women? J Sex Med. 2011; 8:1123–1130. PMID: 21235723.
Article
4. Choi J, Shin DW, Lee S, Jeon MJ, Kim SM, Cho B, et al. Dose-response relationship between cigarette smoking and female sexual dysfunction. Obstet Gynecol Sci. 2015; 58:302–308. PMID: 26217601.
Article
5. Hong H, Lee HJ, Kim SM, Jeon MJ, Shin DW, Choi HC, et al. Subclinical hypothyroidism is not a risk factor for female sexual dysfunction in Korean middle-aged women. Thyroid. 2015; 25:784–788. PMID: 26110199.
Article
6. Keye WR Jr. Psychosexual responses to infertility. Clin Obstet Gynecol. 1984; 27:760–766. PMID: 6488617.
Article
7. Salonia A, Zanni G, Nappi RE, Briganti A, Dehò F, Fabbri F, et al. Sexual dysfunction is common in women with lower urinary tract symptoms and urinary incontinence: results of a cross-sectional study. Eur Urol. 2004; 45:642–648. PMID: 15082208.
Article
8. Thranov I, Klee M. Sexuality among gynecologic cancer patients--a cross-sectional study. Gynecol Oncol. 1994; 52:14–19. PMID: 8307495.
Article
9. Moshesh M, Olshan AF, Saldana T, Baird D. Examining the relationship between uterine fibroids and dyspareunia among premenopausal women in the United States. J Sex Med. 2014; 11:800–808. PMID: 24467730.
Article
10. Ertunc D, Uzun R, Tok EC, Doruk A, Dilek S. The effect of myoma uteri and myomectomy on sexual function. J Sex Med. 2009; 6:1032–1038. PMID: 19040618.
Article
11. Singh SS, Belland L. Contemporary management of uterine fibroids: focus on emerging medical treatments. Curr Med Res Opin. 2015; 31:1–12.
Article
12. Schvartzman R, Bertotto A, Schvartzman L, Wender MC. Pelvic floor muscle activity, quality of life, and sexual function in peri- and recently postmenopausal women with and without dyspareunia: a cross-sectional study. J Sex Marital Ther. 2014; 40:367–378. PMID: 24279742.
Article
13. Baird DD, Hill MC, Schectman JM, Hollis BW. Vitamin D and the risk of uterine fibroids. Epidemiology. 2013; 24:447–453. PMID: 23493030.
Article
14. Kim HY, So HS, Park KS, Jeong SJ, Lee JY, Ryu SB. Development of the Korean-version of Female Sexual Function Index (FSFI). Kor J Androl. 2002; 20:50–56.
15. Wiegel M, Meston C, Rosen R. The Female Sexual Function Index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005; 31:1–20. PMID: 15841702.
Article
16. Dennerstein L, Randolph J, Taffe J, Dudley E, Burger H. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril. 2002; 77(Suppl 4):S42–S48. PMID: 12007901.
Article
17. González M, Viáfara G, Caba F, Molina E. Sexual function, menopause and hormone replacement therapy (HRT). Maturitas. 2004; 48:411–420. PMID: 15283933.
Article
18. Simon JA. Identifying and treating sexual dysfunction in postmenopausal women: the role of estrogen. J Womens Health (Larchmt). 2011; 20:1453–1465. PMID: 21819250.
Article
19. Reed SD, Cushing-Haugen KL, Daling JR, Scholes D, Schwartz SM. Postmenopausal estrogen and progestogen therapy and the risk of uterine leiomyomas. Menopause. 2004; 11:214–222. PMID: 15021452.
Article
20. Islam MS, Protic O, Stortoni P, Grechi G, Lamanna P, Petraglia F, et al. Complex networks of multiple factors in the pathogenesis of uterine leiomyoma. Fertil Steril. 2013; 100:178–193. PMID: 23557758.
Article
21. Randell KM, Honkanen RJ, Tuppurainen MT, Kröger H, Jurvelin JS, Saarikoski S. Fracture risk and bone density of peri- and early postmenopausal women with uterine leiomyomas. Maturitas. 2006; 53:333–342. PMID: 16019169.
Article
Full Text Links
  • YMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr