Soonchunhyang Med Sci.  2019 Jun;25(1):34-36. 10.0000/sms.2019.25.1.34.

Myeloproliferative Neoplasm in Newly Diagnosed Acute Ischemic Stroke Patients

• Chang MH
• Lee JE
• Lee MY
• Kim KH

• KMID: 2452793
• DOI: http://doi.org/10.0000/sms.2019.25.1.34

Abstract

OBJECTIVE
Myeloproliferative neoplasm (MPN) is considered as one of the risk factors of ischemic stroke. Some MPN patients manifest stroke as their first symptom. Our purpose was to assess diagnostic rate of MPN in newly diagnosed acute ischemic stroke patients.
METHODS
This study was performed using National Health Insurance Service Ilsan Hospital dataset. Data retrieving was performed by defining by defining the patient with coding of acute ischemic stroke from January 2013 to June 2017. We selected only the patients who had checked brain magnetic resonance imaging and complete blood cell count (CBC) in emergency room or on admission. Among the results of CBC finding, hemoglobin and platelet count were analyzed. Erythrocytosis was defined >16.5 g/dL (male), >16 g/dL (female) according to revised World Health Organization (WHO) classification of polycythemia vera (PV) criteria. Thrombocytosis was >450,000/µL according to revised WHO classification of essential thrombocythemia (ET).
RESULTS
Total number of newly diagnosed acute ischemic stroke was 1,613 patients. Seven patients (0.43%) were diagnosed MPN (ET=2, PV=5) after ischemic stroke. Patients who had thrombocytosis and erythrocytosis were 18 and 105, respectively. Three patients who had thrombocytosis were diagnosed MPN (ET=2, PV=1). Two patients with erythrocytosis were diagnosed MPN (PV=2). Two patients had both thrombocytosis and erythrocytosis, and two of them were diagnosed PV. Seventy-one patients who had erythrocytosis were normalized in follow-up period. Six patients who had thrombocytosis and 30 patients who had erythrocytosis did not further evaluate.
CONCLUSION
CBC has to be carefully read and MPN can be suspected. Diagnosis must be confirmed by hematologist to initiate appropriate treatment. It is important to recognized suspected MPN patients to prevent stroke.

Keyword

Stroke; Myeloproliferative neoplasm; Erythrocytosis; Thrombocytosis

MeSH Terms

Blood Cell Count
Brain
Classification
Clinical Coding
Dataset
Diagnosis
Emergency Service, Hospital
Follow-Up Studies
Humans
Magnetic Resonance Imaging
National Health Programs
Platelet Count
Polycythemia
Polycythemia Vera
Risk Factors
Stroke*
Thrombocythemia, Essential
Thrombocytosis
World Health Organization