Korean J Pediatr.  2019 May;62(5):173-178. 10.3345/kjp.2018.07024.

The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia

• Manoppo J
• Tasiringan H
• Wahani A
• Umboh A
• Mantik M

• KMID: 2451967
• DOI: http://doi.org/10.3345/kjp.2018.07024

Abstract

PURPOSE
To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA).
METHODS
We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L.
RESULTS
A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from 24.43±1.64 to 28.21±1.72 pg/L (P=0.000). Mean Ret-He level in group 2 changed from 24.31±1.42 to 27.03±2.14 pg/L (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05).
CONCLUSION
Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.

Keyword

Lactobacillus reuteri; Child; Iron deficiency; Anemia

MeSH Terms

Absorption*
Anemia
Anemia, Iron-Deficiency*
Child*
Humans
Indonesia
Iron*
Lactobacillus reuteri*
Lactobacillus*
Non-Randomized Controlled Trials as Topic
Reticulocytes
Iron