Ann Dermatol.  2019 Aug;31(4):476-478. 10.5021/ad.2019.31.4.476.

The Expression of Epidermal Stem Cell Marker and SIRT1 in Atopic Dermatitis: A Discussion of Regenerative Potential

• Shin JW
• Choi HR
• Nam KM
• Yang SH
• Kim SA
• Joe HJ
• Hwang YJ
• Na JI
• Huh CH
• Park KC

• KMID: 2451493
• DOI: http://doi.org/10.5021/ad.2019.31.4.476

Abstract

No abstract available.

MeSH Terms

Dermatitis, Atopic*
Stem Cells*

Figure

• 

  Fig. 1 Expressions of histone deacetylase 1 (HDAC1) and p63 in normal human skin and atopic dermatitis. (A) The number of p63-positive and HDAC1-negative cells (white arrows) was decreased in atopic dermatitis (green: HDAC1 staining, red: p63 staining, ×200; scale bar is 50 µm). (B) The average percentages of epidermal cells with p63-positive/HDAC1-negative staining pattern were significantly lower in atopic dermatitis. SIRT1: sirtuin 1. *p<0.01.

• 

  Fig. 2 Sirtuin 1 (SIRT1) expressions in normal human skin and atopic dermatitis. (A) Expression of SIRT1 was clearly reduced in atopic dermatitis (red: SIRT1, ×200; scale bar is 50 µm). (B) The calculated area of immunohistochemical staining with SIRT1 was significantly smaller in atopic dermatitis. *p<0.01.

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