J Clin Neurol.  2019 Jan;15(1):128-129. 10.3988/jcn.2019.15.1.128.

Acquired Hepatocerebral Degeneration in the Absence of Portosystemic Shunting

• Caranci G
• Cordano C
• Giannini E
• Bandini F

• KMID: 2451159
• DOI: http://doi.org/10.3988/jcn.2019.15.1.128

Abstract

No abstract available.

MeSH Terms

Hepatolenticular Degeneration*
Portasystemic Shunt, Surgical*

Figure

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  Fig. 1 Moderate bilateral pallidus hyperintensities (arrows) in a T1-weighted MRI image.

Reference

1. Ferrara J, Jankovic J. Acquired hepatocerebral degeneration. J Neurol. 2009; 256:320–332.

2. Butterworth RF. Neuronal cell death in hepatic encephalopathy. Metab Brain Dis. 2007; 22:309–320.

3. Liu X, Sullivan KA, Madl JE, Legare M, Tjalkens RB. Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration. Toxicol Sci. 2006; 91:521–531.

4. Rose C, Butterworth RF, Zayed J, Normandin L, Todd K, Michalak A, et al. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology. 1999; 117:640–644.

5. Aggarwal A, Vaidya S, Shah S, Singh J, Desai S, Bhatt M. Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure. Mov Disord. 2006; 21:1986–1990.