Blood Res.  2019 Jun;54(2):149-151. 10.5045/br.2019.54.2.149.

False elevations of vitamin B12 levels due to assay errors in a patient with pernicious anemia

• Iltar U
• Göçer M
• KurtoÄŸlu

• KMID: 2451017
• DOI: http://doi.org/10.5045/br.2019.54.2.149

Abstract

No abstract available.

MeSH Terms

Anemia, Pernicious*
Humans
Vitamin B 12*
Vitamins*
Vitamin B 12
Vitamins

Figure

• 

  Fig. 1 Hematological recovery with supplementation of vitamin B12. a)2U of red blood cells replacement. b)Supplementation of vitamin B12 initiated.

Reference

1. Nexø E, Andersen J. Unsaturated and cobalamin saturated transcobalamin I and II in normal human plasma. Scand J Clin Lab Invest. 1977; 37:723–728.

2. Nexo E, Hoffmann-Lücke E. Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility. Am J Clin Nutr. 2011; 94:359S–365S.

3. Oberley MJ, Yang DT. Laboratory testing for cobalamin deficiency in megaloblastic anemia. Am J Hematol. 2013; 88:522–526.

4. Vlasveld LT, van't Wout JW, Meeuwissen P, Castel A. High measured cobalamin (vitamin B12) concentration attributable to an analytical problem in testing serum from a patient with pernicious anemia. Clin Chem. 2006; 52:157–158. discussion 158-9.

5. van Rossum AP, Vlasveld LT, Castel A. Falsely elevated cobalamin concentration in multiple assays in a patient with pernicious anemia: a case study. Clin Chem Lab Med. 2013; 51:e217–e219.

6. Shah DR, Daver N, Borthakur G, Hirsch-Ginsberg C, Oo TH. Pernicious anemia with spuriously normal vitamin B12 level might be misdiagnosed as myelodysplastic syndrome. Clin Lymphoma Myeloma Leuk. 2014; 14:e141–e143.

7. Shishido T, Hiroshima Y, Uematsu N, et al. Successful treatment with mecobalamin in a pernicious anemia patient presenting with false-normal serum vitamin B12. Rinsho Ketsueki. 2018; 59:675–681.