Infect Chemother.  2019 Jun;51(2):188-190. 10.3947/ic.2019.51.2.188.

Validation of the Uniform Case Definition Criteria for Differentiating Tuberculous Meningitis, Viral Meningitis, and Bacterial Meningitis in Adults

Affiliations
  • 1Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.
  • 2Division of Infectious Diseases, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.
  • 3Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 4Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kimsunghanmd@hotmail.com

Abstract

We validated the uniform case definition for differentiating tuberculous meningitis (TBM) from both viral meningitis (VM) and bacterial meningitis (BM) in adults from South Korea, a country with an intermediate TB-burden. "˜Probable' TBM differentiated "˜definite' TBM with a sensitivity of 81% and specificity of 98%. "˜Possible TBM' criteria identified "˜definite' TBM with a sensitivity of 100% and specificity of 60%. Despite the usefulness of the uniform case definition criteria, there was substantial overlaps among VM, BM, and "˜possible' TBM, especially in severe cases of VM and indolent cases of BM.

Keyword

Tuberculous meningitis; The uniform tuberculous meningitis case definition; Differentiation; Viral meningitis; Bacterial meningitis

MeSH Terms

Adult*
Clothing*
Humans
Korea
Meningitis, Bacterial*
Meningitis, Viral*
Sensitivity and Specificity
Tuberculosis, Meningeal*

Reference

1. Marais S, Thwaites G, Schoeman JF, Török ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010; 10:803–812.
Article
2. Solomons RS, Wessels M, Visser DH, Donald PR, Marais BJ, Schoeman JF, van Furth AM. Uniform research case definition criteria differentiate tuberculous and bacterial meningitis in children. Clin Infect Dis. 2014; 59:1574–1578.
Article
3. Solomons RS, Visser DH, Marais BJ, Schoeman JF, van Furth AM. Diagnostic accuracy of a uniform research case definition for TBM in children: a prospective study. Int J Tuberc Lung Dis. 2016; 20:903–908.
Article
4. Kim SH, Cho OH, Park SJ, Lee EM, Kim MN, Lee SO, Choi SH, Kim YS, Woo JH, Lee SA, Kang JK. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin Infect Dis. 2010; 50:1349–1358.
Article
5. Park KH, Cho OH, Lee EM, Lee SO, Choi SH, Kim YS, Woo JH, Kang JK, Lee SA, Kim SH. T-cell-based assays on cerebrospinal fluid and PBMCs for rapid diagnosis of TB meningitis in non-HIV patients. Eur Respir J. 2012; 39:768–770.
Article
6. Marais BJ, Heemskerk AD, Marais SS, van Crevel R, Rohlwink U, Caws M, Meintjes G, Misra UK, Mai NTH, Ruslami R, Seddon JA, Solomons R, van Toorn R, Figaji A, McIlleron H, Aarnoutse R, Schoeman JF, Wilkinson RJ, Thwaites GE. Tuberculous Meningitis International Research Consortium. Standardized methods for enhanced quality and comparability of tuberculous meningitis studies. Clin Infect Dis. 2017; 64:501–509.
Article
7. Wilkinson RJ, Rohlwink U, Misra UK, van Crevel R, Mai NTH, Dooley KE, Caws M, Figaji A, Savic R, Solomons R, Thwaites GE. Tuberculous Meningitis International Research Consortium. Tuberculous meningitis. Nat Rev Neurol. 2017; 13:581–598.
Article
Full Text Links
  • IC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr