J Gynecol Oncol.  2019 Jul;30(4):e52. 10.3802/jgo.2019.30.e52.

Human papillomavirus genotype-specific risk in cervical carcinogenesis

• So KA
• Lee IH
• Lee KH
• Hong SR
• Kim YJ
• Seo HH
• Kim TJ

• KMID: 2450231
• DOI: http://doi.org/10.3802/jgo.2019.30.e52

Abstract

OBJECTIVE
To evaluate the risk of genotype-specific human papillomavirus (HPV) infections for the spectrum of cervical carcinogenesis and the distribution of HPV types according to age and different cervical lesions
METHODS
This study included HPV-positive women who underwent cervical biopsy at the Cheil General Hospital & Women's Healthcare Center between July 1, 2011 and December 31, 2017. HPV genotyping was conducted using a Cheil HPV DNA chip kit.
RESULTS
The study sample consisted of 400 normal, 399 cervical intraepithelial neoplasia (CIN) 1, 400 CIN 2, 400 CIN 3, and 389 cervical cancer cases. HPV 16 was the most common type found with a prevalence of 9.5% in normal, 6.8% in CIN 1, 15.0% in CIN 2, 44.5% in CIN 3, and 64.3% in cervical cancer. The most common HPV types were 16, 52, 58, 53, 51, 56, 68, and 18 in all study samples. HPV 16, 31, 33, and 58 were more common in CIN 2/3 and cancer, and HPV 39, 51, 53, 56, 66, and 68 were more common in CIN 1 and normal cases (p<0.001). In CIN 3 and cervical cancer, HPV 16 was the most common type in all age groups. HPV 52 was the most common type in CIN 2 (all age groups) and in CIN 1/normal (age ≤30 years) cases. Among the high-risk HPV types, 16, 31, 33, 52, and 58 showed significant risk for high-grade disease.
CONCLUSIONS
HPV 16, 31, 33, 52, and 58 showed the significant risk of high-grade disease for cervical carcinogenesis.

Keyword

Human Papilloma Virus; Genotype; Cervical Intraepithelial Neoplasia; Cervical Cancer

MeSH Terms

Biopsy
Carcinogenesis*
Cervical Intraepithelial Neoplasia
Delivery of Health Care
Female
Genotype
Hospitals, General
Human papillomavirus 16
Humans*
Oligonucleotide Array Sequence Analysis
Papillomaviridae
Prevalence
Uterine Cervical Neoplasms