J Stroke.
2019 May;21(2):207-216. 10.5853/jos.2018.02999.
Early Functional Connectivity Predicts Recovery from Visual Field Defects after Stroke
- Affiliations
-
- 1Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea. dwkang@amc.seoul.kr
- 2Department of Neurology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea.
- 4Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 5Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2449898
- DOI: http://doi.org/10.5853/jos.2018.02999
Abstract
- BACKGROUND AND PURPOSE
We aimed to assess whether early resting-state functional connectivity (RSFC) changes measured via functional magnetic resonance imaging (fMRI) could predict recovery from visual field defect (VFD) in acute stroke patients.
METHODS
Patients with VFD due to acute ischemic stroke in the visual cortex and age-matched healthy controls were prospectively enrolled. Serial resting-state (RS)-fMRI and Humphrey visual field (VF) tests were performed within 1 week and at 1 and 3 months (additional VF test at 6 months) after stroke onset in the patient group. The control group also underwent RS-fMRI and a Humphrey VF test. The changes in RSFCs and VF scores (VFSs) over time and their correlations were investigated.
RESULTS
In 32 patients (65±10 years, 25 men), the VFSs were lower and the interhemispheric RSFC in the visual cortices was decreased compared to the control group (n=15, 62±6 years, seven men). The VFSs and interhemispheric RSFC in the visual cortex increased mainly within the first month after stroke onset. The interhemispheric RSFC and VFSs were positively correlated at 1 month after stroke onset. Moreover, the interhemispheric RSFCs in the visual cortex within 1 week were positively correlated with the follow-up VFSs.
CONCLUSIONS
Interhemispheric RSFCs in the visual cortices within 1 week after stroke onset may be a useful biomarker to predict long-term VFD recovery.
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