Int J Thyroidol.  2019 May;12(1):1-8. 10.11106/ijt.2019.12.1.1.

Understanding Neoplasm of Uncertain or Unknown Behavior of the Thyroid in Korean Clinical Practice

Affiliations
  • 1Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ckjung@catholic.ac.kr
  • 2Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Thyroid tumors include a heterogeneous group of entities with variable clinical behavior and histology, mostly classified as benign or malignant. Neoplasm of uncertain or unknown behavior in thyroid gland was newly adopted by the 2017 edition of World Health Organization (WHO) classification of endocrine organs. The borderline thyroid tumors include a hyalinizing trabecular tumor and three encapsulated follicular-patterned thyroid tumors (follicular tumor of uncertain malignant potential, well-differentiated tumor of uncertain malignant potential, and non-invasive follicular thyroid neoplasm with papillary-like nuclear features). This review summarizes the changes in the 2017 WHO classification of thyroid tumors, highlights their implications for clinical practice in Korea, and briefly discusses National Health Insurance system, cancer insurance policies, and their associated benefits in Korea.

Keyword

Borderline tumor; Non-invasive follicular thyroid neoplasm with papillary-like nuclear features; Thyroid neoplasm; Cancer insurance

MeSH Terms

Classification
Hyalin
Insurance
Korea
National Health Programs
Thyroid Gland*
Thyroid Neoplasms
World Health Organization

Figure

  • Fig. 1 Schematic illustration of encapsulated follicular-patterned thyroid tumors on the basis of presence or absence of nuclear features of papillary thyroid carcinoma and capsular or vascular invasion by 2017 World Health Organization classification. EFVPTC: encapsulated follicular variant of papillary thyroid carcinoma, FT-UMP: follicular tumor of uncertain malignant potential, NIFTP: non-invasive follicular thyroid neoplasm with papillary-like nuclear features, WDC-NOS: well-differentiated carcinoma, not otherwise specified, WDT-UMP: well-differentiated tumor of uncertain malignant potential


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