Korean J Ophthalmol.  2019 Jun;33(3):296-297. 10.3341/kjo.2018.0080.

Precipitation of Vancomycin and Ceftazidime on Intravitreal Injection in Endophthalmitis Patients

Affiliations
  • 1Department of Ophthalmology, Kosin University College of Medicine, Busan, Korea. hiatus@kosin.ac.kr

Abstract

No abstract available.


MeSH Terms

Ceftazidime*
Endophthalmitis*
Humans
Intravitreal Injections*
Vancomycin*
Ceftazidime
Vancomycin

Figure

  • Fig. 1 Photographs of the procedure. (A) Intravitreal antibiotic injection with a 30G needle and 1cc syringe. (B) After pars plana vitrectomy and intravitreal injection. The presence of precipitation (arrow) on the endophthalmitis patient's fundus (surgeon view). Written informed consent from the patient was obtained.


Reference

1. Roth DB, Flynn HW Jr. Antibiotic selection in the treatment of endophthalmitis: the significance of drug combinations and synergy. Surv Ophthalmol. 1997; 41:395–401.
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2. Lifshitz T, Lapid-Gortzak R, Finkelman Y, Klemperer I. Vancomycin and ceftazidime incompatibility upon intravitreal injection. Br J Ophthalmol. 2000; 84:117–118.
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3. Raju B, Bali T, Thiagarajan G, et al. Physicochemical properties and antibacterial activity of the precipitate of vancomycin and ceftazidime: implications in the management of endophthalmitis. Retina. 2008; 28:320–325.
4. Kwok AK, Hui M, Pang CP, et al. An in vitro study of ceftazidime and vancomycin concentrations in various fluid media: implications for use in treating endophthalmitis. Invest Ophthalmol Vis Sci. 2002; 43:1182–1188.
5. Park I, Lee SJ. Factors affecting precipitation of vancomycin and ceftazidime on intravitreal injection. J Ocul Pharmacol Ther. 2013; 29:23–26.
Article
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