Allergy Asthma Immunol Res.  2019 Jul;11(4):572-582. 10.4168/aair.2019.11.4.572.

Association of Sensitization to Different Aeroallergens With Airway Function and Nasal Patency in Urban Children

• Lee S
• Koh HY
• Yon DK
• Lee SW
• Ha EK
• Sung M
• Lee KS
• Jee HM
• Sheen YH
• Han MY

• KMID: 2448759
• DOI: http://doi.org/10.4168/aair.2019.11.4.572

Abstract

PURPOSE
Children with sensitization to aeroallergens have decreased lung function and nasal patency. Our purpose was to determine the association of sensitization to different aeroallergens with airway function and nasal patency.
METHODS
Four hundred and eighty-six randomly selected 11 year-old children who lived in Seongnam City were examined. Serum specific immunoglobulin E (IgE) levels against 6 common allergens (Dermatophagoidesfarinae, birch, cat, dog, Japanese hop and Alternaria), impulse oscillometry (IOS) results for the evaluation of airway dysfunction, and acoustic rhinometry for the determination of nasal airway patency were obtained.
RESULTS
IOS indicated that children sensitized to Alternaria (n = 38, 7.8%) and dog dander (n = 69, 14.2%) had decreased lung function, based on resistance at 10 Hz (Rrs10; aβ = 0.0072; 95% CI, 0.017, 0.127; P = 0.010) and 1 Hz (Rrs1; aβ = 0.038; 95% CI, 0.001, 0.074; P = 0.042). Children sensitized to D. farinae (n = 281, 57.8%) had decreased post-decongestant nasal volume at 0 to 5 cm (aβ = −0.605; 95% CI, −1.005, −0.205; P = 0.003), but normal IOS results at all measured frequencies (P > 0.05). Increased serum eosinophil level was associated with Rrs1 (P = 0.007) and Rrs2 (P = 0.018) and post-decongestant nasal volume at 0 to 5 cm (aβ = −0.885; 95% CI, −1.331, −0.439; P < 0.001).
CONCLUSIONS
Sensitivity to specific aeroallergens, serum eosinophil count and total IgE level had different associations with upper and lower airway dysfunction in urban children.

Keyword

Lung function tests; oscillometry; rhinometry; allergens; eosinophil count

MeSH Terms

Allergens
Alternaria
Animals
Asian Continental Ancestry Group
Betula
Cats
Child*
Dander
Dogs
Eosinophils
Gyeonggi-do
Humans
Immunoglobulin E
Immunoglobulins
Jupiter
Lung
Oscillometry
Respiratory Function Tests
Rhinometry, Acoustic
Allergens
Immunoglobulin E
Immunoglobulins

Figure

• 

  Figure Locally weighted scatterplot smoothing of impulse oscillometry resistance at 1, 2, 3, 5, 10, 15 and 20 Hz for 6 aeroallergens. Shaded areas indicate 80% confidence intervals. Sensitization to Alternaria (D) was significantly associated with Rrs10, Rrs15, and Rrs20 and sensitization to Dog (C) was significantly associated with Rrs1. Sensitization to D. farinae (A), Cat (B), Birch (E) and Japanese hop (F) were not significantly associated with small airway dysfunction at any tested frequency. IgE, immunoglobulin E.

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