Asian Spine J.  2019 Apr;13(2):296-304. 10.31616/asj.2018.0145.

En Bloc Spondylectomy for Spinal Metastases: Detailed Oncological Outcomes at a Minimum of 2 Years after Surgery

• Ohashi M
• Hirano T
• Watanabe K
• Hasegawa K
• Ito T
• Katsumi K
• Shoji H
• Mizouchi T
• Takahashi
• Homma T
• Endo N

• KMID: 2447537
• DOI: http://doi.org/10.31616/asj.2018.0145

Abstract

STUDY DESIGN: Retrospective case series. PURPOSE: To investigate the oncological outcomes, including distant relapse, after en bloc spondylectomy (EBS) for spinal metastases in patients with a minimum of 2-year follow-up. OVERVIEW OF LITERATURE: Although EBS has been reported to be locally curative and extend survival in select patients with spinal metastases, detailed reports regarding the control of distant relapse after EBS are lacking.
METHODS
We conducted a retrospective review of 18 consecutive patients (median age at EBS, 62 years; range, 40-77 years) who underwent EBS for spinal metastases between 1991 and 2015. The primary cancer sites included the kidney (n=7), thyroid (n=4), liver (n=3), and other locations (n=4). Survival rates were estimated using the Kaplan-Meier method, and groups were compared using the log-rank method.
RESULTS
The median operative time and intraoperative blood loss were 767.5 minutes and 2,375 g, respectively. Twelve patients (66.7%) experienced perioperative complications. Five patients (27.8%) experienced local recurrence of the tumor at a median of 12.5 months after EBS, four of which had a positive resection margin status. Thirteen patients (72.2%) experienced distant relapse at a median of 21 months after EBS. The estimated median survival period after distant relapse was 20 months (95% confidence interval, 0.71-39.29 months). No association was found between resection margin status and distant relapse. Overall, the 2-year, 5-year, and 10-year survival rates after EBS were 72.2%, 48.8%, and 27.1%, respectively. Importantly, the era in which EBS was performed did not impact the oncological outcomes.
CONCLUSIONS
Our results suggest that EBS by itself, even if margin-free, cannot prevent further dissemination, which occurred in >70% of patients at a median of 21 months after EBS. These results should be considered and conveyed to patients for clinical decision-making.

Keyword

Spine; Neoplasm metastasis; Margins of excision; Recurrence; Survival

MeSH Terms

Clinical Decision-Making
Follow-Up Studies
Humans
Kidney
Liver
Methods
Neoplasm Metastasis*
Operative Time
Recurrence
Retrospective Studies
Spine
Survival Rate
Thyroid Gland