Urogenit Tract Infect.  2019 Apr;14(1):9-13. 10.14777/uti.2019.14.1.9.

Perioperative Risk Factors Related to Systemic Inflammatory Response Syndrome after Percutaneous Nephrolithotomy

• Chung HS
• Jung SI

• KMID: 2445082
• DOI: http://doi.org/10.14777/uti.2019.14.1.9

Abstract

Percutaneous nephrolithotomy (PCNL) has become the standard treatment for large and complex kidney stones since its introduction in 1976. On the other hand, postoperative complications are not rare and can be quite significant. Of these complications, postoperative infectious complications, such as systemic inflammatory response syndrome (SIRS), remain a seminal event and a possible cause of perioperative mortality. Several recent studies have found a number of factors that increase the risk of SIRS after PCNL. These include preoperative factors (patient's characteristics) and factors associated with the intraoperative and postoperative findings. The present study describes the perioperative risk factors of SIRS after PCNL. These findings can help decrease the incidence of infectious complications, including SIRS, in patients undergoing PCNL.

Keyword

Percutaneous nephrolithotomy; Risk factors; Systemic inflammatory response syndrome; Urinary tract infections

MeSH Terms

Hand
Humans
Incidence
Kidney Calculi
Mortality
Nephrostomy, Percutaneous*
Postoperative Complications
Risk Factors*
Systemic Inflammatory Response Syndrome*
Urinary Tract Infections

Reference

References

1. Fernstrom I, Johansson B. Percutaneous pyelolithotomy. A new extraction technique. Scand J Urol Nephrol. 1976; 10:257–9.

2. de la Rosette J, Assimos D, Desai M, Gutierrez J, Lingeman J, Scarpa R, et al. CROES PCNL Study Group. The Clinical Research Office of the Endourological Society percutaneous nephrolithotomy global study: indications, complications, and outcomes in 5803 patients. J Endourol. 2011; 25:11–7.

3. Lai WS, Assimos D. Factors associated with postoperative infection after percutaneous nephrolithotomy. Rev Urol. 2018; 20:7–11.

4. Deshmukh S, Sternberg K, Hernandez N, Eisner BH. Compliance with American Urological Association guidelines for postpercutaneous nephrolithotomy antibiotics does not appear to increase rates of infection. J Urol. 2015; 194:992–6.

5. Wollin DA, Joyce AD, Gupta M, Wong MYC, Laguna P, Gravas S, et al. Antibiotic use and the prevention and management of infectious complications in stone disease. World J Urol. 2017; 35:1369–79.

6. Ivan SJ, Sindhwani P. Comparison of guideline recommendations for antimicrobial prophylaxis in urologic procedures: variability, lack of consensus, and contradictions. Int Urol Nephrol. 2018; 50:1923–37.

7. Chen L, Xu QQ, Li JX, Xiong LL, Wang XF, Huang XB. Systemic inflammatory response syndrome after percutaneous nephrolithotomy: an assessment of risk factors. Int J Urol. 2008; 15:1025–8.

8. Singh P, Yadav S, Singh A, Saini AK, Kumar R, Seth A, et al. Systemic inflammatory response syndrome following percutaneous nephrolithotomy: assessment of risk factors and their impact on patient outcomes. Urol Int. 2016; 96:207–11.

9. He Z, Tang F, Lei H, Chen Y, Zeng G. Risk factors for systemic inflammatory response syndrome after percutaneous nephrolithotomy. Prog Urol. 2018; 28:582–7.

10. Erdil T, Bostanci Y, Ozden E, Atac F, Yakupoglu YK, Yilmaz AF, et al. Risk factors for systemic inflammatory response syndrome following percutaneous nephrolithotomy. Urolithiasis. 2013; 41:395–401.

11. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003; 29:530–8.

12. Wei W, Leng J, Shao H, Wang W. Diabetes, a risk factor for both infectious and major complications after percutaneous nephrolithotomy. Int J Clin Exp Med. 2015; 8:16620–6.

13. Draga RO, Kok ET, Sorel MR, Bosch RJ, Lock TM. Percutaneous nephrolithotomy: factors associated with fever after the first postoperative day and systemic inflammatory response syndrome. J Endourol. 2009; 23:921–7.

14. Korets R, Graversen JA, Kates M, Mues AC, Gupta M. Post-percutaneous nephrolithotomy systemic inflammatory response: a prospective analysis of preoperative urine, renal pelvic urine and stone cultures. J Urol. 2011; 186:1899–903.

15. Cetinkaya M, Buldu I, Kurt O, Inan R. Platelet-to-lymphocyte ratio: a new factor for predicting systemic inflammatory response syndrome after percutaneous nephrolithotomy. Urol J. 2017; 14:4089–93.

16. Sharifi Aghdas F, Akhavizadegan H, Aryanpoor A, Inanloo H, Karbakhsh M. Fever after percutaneous nephrolithotomy: contributing factors. Surg Infect (Larchmt). 2006; 7:367–71.

17. Yang T, Liu S, Hu J, Wang L, Jiang H. The evaluation of risk factors for postoperative infectious complications after percutaneous nephrolithotomy. Biomed Res Int. 2017; 2017:4832051.

18. Mariappan P, Smith G, Bariol SV, Moussa SA, Tolley DA. Stone and pelvic urine culture and sensitivity are better than bladder urine as predictors of urosepsis following percutaneous nephrolithotomy: a prospective clinical study. J Urol. 2005; 173:1610–4.

19. Walton-Diaz A, Vinay JI, Barahona J, Daels P, Gonzalez M, Hidalgo JP, et al. Concordance of renal stone culture: PMUC, RPUC, RSC and post-PCNL sepsis-a non-randomized prospective observation cohort study. Int Urol Nephrol. 2017; 49:31–5.

20. Chew BH, Miller NL, Abbott JE, Lange D, Humphreys MR, Pais VM Jr, et al. A randomized controlled trial of preoperative prophylactic antibiotics prior to percutaneous nephrolithotomy in a low infectious risk population: a report from the EDGE consortium. J Urol. 2018; 200:801–8.

21. Singh I, Shah S, Gupta S, Singh NP. Efficacy of intraoperative renal stone culture in predicting postpercutaneous nephrolithotomy urosepsis/systemic inflammatory response syndrome: a prospective analytical study with review of literature. J Endourol. 2019; 33:84–92.

22. Rivera M, Viers B, Cockerill P, Agarwal D, Mehta R, Krambeck A. Pre-and postoperative predictors of infection-related complications in patients undergoing percutaneous nephrolithotomy. J Endourol. 2016; 30:982–6.

23. Ronald A, Ludwig E. Urinary tract infections in adults with diabetes. Int J Antimicrob Agents. 2001; 17:287–92.

24. Gutierrez J, Smith A, Geavlete P, Shah H, Kural AR, de Sio M, et al. Urinary tract infections and postoperative fever in percutaneous nephrolithotomy. World J Urol. 2013; 31:1135–40.

25. Giubilato S, Liuzzo G, Brugaletta S, Pitocco D, Graziani F, Smaldone C, et al. Expansion of CD4+CD28null T-lymphocytes in diabetic patients: exploring new pathogenetic mechanisms of increased cardiovascular risk in diabetes mellitus. Eur Heart J. 2011; 32:1214–26.

26. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013; 39:165–228.

27. Margel D, Ehrlich Y, Brown N, Lask D, Livne PM, Lifshitz DA. Clinical implication of routine stone culture in percutaneous nephrolithotomy–a prospective study. Urology. 2006; 67:26–9.

28. Patel N, Shi W, Liss M, Raheem O, Wenzler D, Schallhorn C, et al. Multidrug resistant bacteriuria before percutaneous nephrolithotomy predicts for postoperative infectious complications. J Endourol. 2015; 29:531–6.

29. Sen V, Bozkurt IH, Aydogdu O, Yonguc T, Yarimoglu S, Sen P, et al. Significance of preoperative neutrophil-lymphocyte count ratio on predicting postoperative sepsis after percutaneous nephrolithotomy. Kaohsiung J Med Sci. 2016; 32:507–13.

30. Ganesan V, Brown RD, Jimenez JA, De S, Monga M. C-reactive protein and erythrocyte sedimentation rate predict systemic inflammatory response syndrome after percutaneous nephrolithotomy. J Endourol. 2017; 31:638–44.

31. Mariappan P, Smith G, Moussa SA, Tolley DA. One week of ciprofloxacin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study. BJU Int. 2006; 98:1075–9.

32. Omar M, Noble M, Sivalingam S, El Mahdy A, Gamal A, Farag M, et al. Systemic inflammatory response syndrome after percutaneous nephrolithotomy: a randomized single-blind clinical trial evaluating the impact of irrigation pressure. J Urol. 2016; 196:109–14.

33. Roushani A, Falahatkar S, Sharifi SH, Mahfoozi L, Saadat SM, Allahkhah A, et al. Intraoperative stone culture as an independent predictor of systemic inflammatory response syndrome after percutaneous nephrolithotomy. Urolithiasis. 2014; 42:455–9.

34. Lojanapiwat B, Kitirattrakarn P. Role of preoperative and intraoperative factors in mediating infection complication following percutaneous nephrolithotomy. Urol Int. 2011; 86:448–52.

35. Kreydin EI, Eisner BH. Risk factors for sepsis after percutaneous renal stone surgery. Nat Rev Urol. 2013; 10:598–605.

36. McAleer IM, Kaplan GW, Bradley JS, Carroll SF, Griffith DP. Endotoxin content in renal calculi. J Urol. 2003; 169:1813–4.

37. Degirmenci T, Bozkurt IH, Celik S, Yarimoglu S, Basmaci I, Sefik E. Does leaving residual fragments after percutaneous nephrolithotomy in patients with positive stone culture and/or renal pelvic urine culture increase the risk of infectious complications? Urolithiasis 2018 Jun 4 [Epub]. DOI: 10.1007/s00240-018-1063-9.

38. Ramaraju K, Paranjothi AK, Namperumalsamy DB, Chen-nakrishnan I. Predictors of systemic inflammatory response syndrome following percutaneous nephrolithotomy. Urol Ann. 2016; 8:449–53.

39. Shoshany O, Margel D, Finz C, Ben-Yehuda O, Livne PM, Holand R, et al. Percutaneous nephrolithotomy for infection stones: what is the risk for postoperative sepsis? A retrospective cohort study. Urolithiasis. 2015; 43:237–42.