Investig Clin Urol.  2019 May;60(3):195-201. 10.4111/icu.2019.60.3.195.

Use of docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in Korean patients: A retrospective study

Affiliations
  • 1Department of Urology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
  • 2Department of Urology, Urological Cancer Center, National Cancer Center, Goyang, Korea.
  • 3Department of Urology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
  • 4Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cskim@amc.seoul.kr

Abstract

PURPOSE
We aimed to evaluate the efficacy and safety of the use of docetaxel plus androgen deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC) in Korean patients.
MATERIALS AND METHODS
This study was conducted retrospectively. In total, 61 Korean patients with mHSPC who used docetaxel plus ADT were identified from medical records. Patients received docetaxel plus ADT at a dose of 75 mg/m2 every 3 weeks for 6 cycles. We evaluated prostate-specific antigen (PSA) response, PSA progression, progression to castration-resistant prostate cancer (CRPC), clinical progression, and adverse events.
RESULTS
Most of the patients had high volume disease (98.3%) and 83.6% had a Gleason score of 8 or higher. The median PSA level at the start of ADT was 131.4 ng/mL. The percentage of patients whose PSA levels decreased to less than 0.2 ng/mL at 3, 6, and 12 months were 28.3%, 41.0%, and 45.0%, respectively. During a median of 12.0 months after treatment, PSA progression occurred in 13.3% of patients. Clinical progression and progression to CRPC were observed in 15.1% and 14.8%, respectively. Neutropenia grade ≥3 and febrile neutropenia occurred in 63.5% and 11.5%, respectively.
CONCLUSIONS
Comparing our findings with those of the prior chemohormonal therapy versus androgen ablation randomized trial for extensive disease in prostate cancer (CHAARTED) study, in Korean patients, the use of docetaxel plus ADT for mHSPC showed similar results for early oncologic outcomes including PSA response and time to clinical progression. However, we observed a higher rate of adverse events, which should be considered seriously.

Keyword

Androgens; Docetaxel; Drug therapy; Prostatic neoplasms

MeSH Terms

Androgens
Drug Therapy
Febrile Neutropenia
Humans
Medical Records
Neoplasm Grading
Neutropenia
Prostate*
Prostate-Specific Antigen
Prostatic Neoplasms*
Retrospective Studies*
Androgens
Prostate-Specific Antigen
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