Perinatology.  2019 Mar;30(1):20-26. 10.14734/PN.2019.30.1.20.

Respiratory Outcomes at 12 Months of Corrected Age of Preterm Infants with Severe Bronchopulmonary Dysplasia Requiring Protracted Invasive Ventilation

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. revival421@snu.ac.kr

Abstract


OBJECTIVE
The objective of this study was to describe respiratory and neurodevelopmental outcomes in infants with severe bronchopulmonary dysplasia (BPD) who needed invasive ventilation until 36 weeks' postmenstrual age (PMA).
METHODS
A retrospective observational single-center study was conducted in our hospital. Eighty preterm infants born between January 2007 and December 2016 with less than 28 weeks' gestational age and classified as having severe BPD were included in the study. Patients with invasive ventilation at 36 weeks' PMA (invasive group) were compared with those with noninvasive ventilation (noninvasive group) in terms of perinatal characteristics and postnatal outcomes.
RESULTS
Antenatal characteristics and basic patient characteristics were comparable between the two groups. Incidence of pulmonary hemorrhage (13.6 vs. 1.7%, P=0.061) and clinical sepsis (66.7 vs. 31.0%, P=0.004) was more in the invasive group. Invasive group had longer hospital stay (133.50±104.52 vs. 114.00±24.71 days, P=0.031), higher rates of readmission due to respiratory problems before 12 months of corrected age (57.1 vs. 32.1%, P=0.045), higher rates of having a tracheostomy (22.7 vs. 1.7%, P=0.005), and higher rates of infants with respiratory support at a corrected age of 6 months (22.7 vs. 3.5%, P=0.016). Neurodevelopmental outcomes including Bayley Scales of Infant Development-III, cerebral palsy, hearing aid, blindness, and composite outcome of them revealed no differences between the two groups.
CONCLUSION
Invasive ventilation until postmenstrual age of 36 weeks does not predict poorer neurodevelopmental outcomes in infants with severe BPD. However, the invasive group was more prone to develop respiratory problems after discharge.

Keyword

Preterm infants; Bronchopulmonary dysplasia; Respiration; Artificial; Growth and Development; Lung injury

MeSH Terms

Blindness
Bronchopulmonary Dysplasia*
Cerebral Palsy
Gestational Age
Growth and Development
Hearing Aids
Hemorrhage
Humans
Incidence
Infant
Infant, Newborn
Infant, Premature*
Length of Stay
Lung Injury
Noninvasive Ventilation
Respiration
Retrospective Studies
Sepsis
Tracheostomy
Ventilation*
Weights and Measures
Full Text Links
  • PN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr