Dement Neurocogn Disord.  2018 Dec;17(4):131-136. 10.12779/dnd.2018.17.4.131.

Genetics of Alzheimer's Disease

• Kim JH

• KMID: 2442783
• DOI: http://doi.org/10.12779/dnd.2018.17.4.131

Abstract

Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP, PSEN1, PSEN2, ABCA7, and SORL1. Genome-wide association studies have found risk genes such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-HLA-DRB1, INPP5D, MEF2C, MS4A6A/MS4A4E, NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1. ABCA7, SORL1, TREM2, and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.

Keyword

Alzheimer's Disease; Genetics; CRISPR-Cas Systems; Single-Cell Analysis

MeSH Terms

Alzheimer Disease*
Apolipoproteins E
CRISPR-Cas Systems
Genetic Techniques
Genetics*
Genome-Wide Association Study
Odds Ratio
Sequence Analysis, RNA
Single-Cell Analysis
Apolipoproteins E

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