Infect Chemother.  2019 Mar;51(1):67-72. 10.3947/ic.2019.51.1.67.

Changes in Serotype of Streptococcus pneumoniae After the Introduction of the 13-Valent Pneumococcal Vaccine in a Homogenous Population on Jeju Island

• Yoo JR
• Heo ST
• Oh H
• Oh S
• Kim YR
• Lee KH

• KMID: 2442225
• DOI: http://doi.org/10.3947/ic.2019.51.1.67

Abstract

We compared the serotypes of Streptococcus pneumoniae between the pre-pneumococcal conjugate vaccine (PCV)13 era and post-PCV13 era among homogenous inhabitants of an isolated South Korean island. A total of 325 S. pneumoniae strains were isolated. In the pre-PCV13 era, 19A/F, 15A/F, 19B, and 23A serotypes were identified. In the post-PCV13 era, 15 serotypes were identified. The 19F and 23A serotypes showed the highest prevalence in the pre- and post-PCV13 era, respectively. After PCV13 introduction, the PCV 13 serotype coverage rate was decreased (80.0% and 30.5% in the pre- and post-PCV13 eras, respectively), while the proportion of non-PCV 13 serotypes increased.

Keyword

Streptococcus pneumonia; vaccination; PCV 13 vaccine; Jeju Island; Korea

MeSH Terms

Korea
Pneumonia
Prevalence
Serogroup*
Streptococcus pneumoniae*
Streptococcus*
Vaccination

Figure

• 

  Figure 1 Serotype distribution of Streptococcus pneumoniae between the pre-PCV13 vaccination period and post-PCV13 vaccination period. aPCV13 serotype. bPPV23 serotype. cNon-vaccination serotype. Purple bars indicate the serotype of S. pneumoniae in the pre-PCV13 period, orange bars indicated the serotype of S. pneumoniae in the post-PCV13 period. PCV, pneumococcal conjugated vaccine.

Reference

1. Kim JH, Baik SH, Chun BC, Song JY, Bae IG, Kim HY, Kim DM, Choi YH, Choi WS, Jo YM, Kwon HH, Jeong HW, Kim YS, Kim JY, Lee J, Kee SY, Hur J, Chung JW, Hwang KE, Kim MJ. Adult invasive pneumococcal disease in the Republic of Korea: risk medical conditions and mortality stratified to age groups. Int J Infect Dis. 2018; 74:136–144.

2. Lee JK, Yun KW, Choi EH, Kim SJ, Lee SY, Lee HJ. Changes in the serotype distribution among antibiotic resistant carriage Streptococcus pneumoniae isolates in children after the introduction of the extended-valency pneumococcal conjugate vaccine. J Korean Med Sci. 2017; 32:1431–1439.

3. Choi WS, Choi JH, Kwon KT, Seo K, Kim MA, Lee SO, Hong YJ, Lee JS, Song JY, Bang JH, Choi HJ, Choi YH, Lee DG, Cheong HJ. Committee of Adult Immunization. Korean Society of Infectious Diseases. Revised adult immunization guideline recommended by the Korean Society of Infectious Diseases, 2014. Infect Chemother. 2015; 47:68–79.

4. Jackson LA, Gurtman A, van Cleeff M, Jansen KU, Jayawardene D, Devlin C, Scott DA, Emini EA, Gruber WC, Schmoele-Thoma B. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults. Vaccine. 2013; 31:3577–3584.

5. Vila-Corcoles A, Ochoa-Gondar O. Preventing pneumococcal disease in the elderly: recent advances in vaccines and implications for clinical practice. Drugs Aging. 2013; 30:263–276.

6. Hausdorff WP, Feikin DR, Klugman KP. Epidemiological differences among pneumococcal serotypes. Lancet Infect Dis. 2005; 5:83–93.

7. Leung MH, Bryson K, Freystatter K, Pichon B, Edwards G, Charalambous BM, Gillespie SH. Sequetyping: serotyping Streptococcus pneumoniae by a single PCR sequencing strategy. J Clin Microbiol. 2012; 50:2419–2427.

8. Feng Z, Hill AN, Smith PJ, Glasser JW. An elaboration of theory about preventing outbreaks in homogeneous populations to include heterogeneity or preferential mixing. J Theor Biol. 2015; 386:177–187.

9. Bonten MJ, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, van Werkhoven CH, van Deursen AM, Sanders EA, Verheij TJ, Patton M, McDonough A, Moradoghli-Haftvani A, Smith H, Mellelieu T, Pride MW, Crowther G, Schmoele-Thoma B, Scott DA, Jansen KU, Lobatto R, Oosterman B, Visser N, Caspers E, Smorenburg A, Emini EA, Gruber WC, Grobbee DE. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015; 372:1114–1125.

10. Lee S, Bae S, Lee KJ, Yu JY, Kang Y. Changes in serotype prevalence and antimicrobial resistance among invasive Streptococcus pneumoniae isolates in Korea, 1996-2008. J Med Microbiol. 2013; 62:1204–1210.

11. Balsells E, Guillot L, Nair H, Kyaw MH. Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis. PLoS One. 2017; 12:e0177113.

12. Zuccotti G, Mameli C, Daprai L, Garlaschi ML, Dilillo D, Bedogni G, Faccini M, Gramegna M, Torresani E. PneuMi Study Group (PMSG). Ballerini E, Benincaso A, Bonvissuto M, Bricalli D, Brioschi M, Calloni CS, Camiletti MI, Colella G, De Angelis L, Decarlis S, Di Nello F, Dozzi M, Galli E, Gandini V, Giuliani MG, Laviola F, Loda B, Macedoni M, Mazzucchi E, Metta MG, Moscatiello A, Nannini P, Petruzzi M, Picicco D, Picciotti M, Pisanelli S, Porta N, Ramponi G, Redaelli F, Rubini R, Sala N, Saitta V, Scelza G, Tiso RM, Tomasetto M, Torcoletti M, Travaini M, Valentini M, Vessia C. Serotype distribution and antimicrobial susceptibilities of nasopharyngeal isolates of Streptococcus pneumoniae from healthy children in the 13-valent pneumococcal conjugate vaccine era. Vaccine. 2014; 32:527–534.