Infect Chemother.  2019 Mar;51(1):67-72. 10.3947/ic.2019.51.1.67.

Changes in Serotype of Streptococcus pneumoniae After the Introduction of the 13-Valent Pneumococcal Vaccine in a Homogenous Population on Jeju Island

Affiliations
  • 1Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. neosangtaek@naver.com
  • 2Department of Laboratory Medicine, Jeju National University School of Medicine, Jeju, Korea.
  • 3Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea.

Abstract

We compared the serotypes of Streptococcus pneumoniae between the pre-pneumococcal conjugate vaccine (PCV)13 era and post-PCV13 era among homogenous inhabitants of an isolated South Korean island. A total of 325 S. pneumoniae strains were isolated. In the pre-PCV13 era, 19A/F, 15A/F, 19B, and 23A serotypes were identified. In the post-PCV13 era, 15 serotypes were identified. The 19F and 23A serotypes showed the highest prevalence in the pre- and post-PCV13 era, respectively. After PCV13 introduction, the PCV 13 serotype coverage rate was decreased (80.0% and 30.5% in the pre- and post-PCV13 eras, respectively), while the proportion of non-PCV 13 serotypes increased.

Keyword

Streptococcus pneumonia; vaccination; PCV 13 vaccine; Jeju Island; Korea

MeSH Terms

Korea
Pneumonia
Prevalence
Serogroup*
Streptococcus pneumoniae*
Streptococcus*
Vaccination

Figure

  • Figure 1 Serotype distribution of Streptococcus pneumoniae between the pre-PCV13 vaccination period and post-PCV13 vaccination period. aPCV13 serotype. bPPV23 serotype. cNon-vaccination serotype. Purple bars indicate the serotype of S. pneumoniae in the pre-PCV13 period, orange bars indicated the serotype of S. pneumoniae in the post-PCV13 period. PCV, pneumococcal conjugated vaccine.


Cited by  1 articles

Invasive Pneumococcal Disease Caused by Non-Vaccine Type Multidrug-Resistant Streptococcus pneumoniae Transmitted by Close Contact in a Healthy Adult
Jeong Rae Yoo, Suhyun Oh, Jae-Geun Lee, Young Ree Kim, Keun Hwa Lee, Sang Taek Heo
Yonsei Med J. 2019;60(11):1103-1107.    doi: 10.3349/ymj.2019.60.11.1103.


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