Tissue Eng Regen Med.  2018 Dec;15(6):699-709. 10.1007/s13770-018-0143-9.

Current Status of Stem Cell Treatment for Type I Diabetes Mellitus

• Kakkar A
• Sorout A
• Tiwari M
• Shrivastava P
• Meena P
• Saraswat S
• Srivastava S
• Datt R
• Pandey S

• KMID: 2441262
• DOI: http://doi.org/10.1007/s13770-018-0143-9

Abstract

BACKGROUND
Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans.
METHODS
Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into β islet cells.
RESULTS
These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms.
CONCLUSION
Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.

Keyword

Diabetes mellitus; Stem cells; In vitro differentiation; Bone marrow

MeSH Terms

Bone Marrow
Diabetes Mellitus*
Diabetes Mellitus, Type 1
Global Health
Humans
In Vitro Techniques
Insulin
Islets of Langerhans
Mesenchymal Stromal Cells
Models, Animal
Stem Cell Transplantation
Stem Cells*
Insulin