Korean J Intern Med.  2019 Mar;34(2):353-364. 10.3904/kjim.2016.285.

Non-fasting triglyceride levels in the Korean population with and without ischemic heart disease and cerebrovascular disease

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mkmoon@snu.ac.kr
  • 2Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.

Abstract

BACKGROUND/AIMS
Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans.
METHODS
We conducted an analysis of patients aged ≥ 30 years from the nationwide survey database. Fasting TG was defined as a measurement taken ≥ 12 hours since the last meal. Non-fasting TG was categorized by fasting duration of 0 to 3, 4 to 7, and 8 to 11 hours.
RESULTS
In subjects without history of IHD/CVA, diabetes, or lipid-lowering medication, the TG level was significantly elevated for 7 hours in men compared to fasting TG levels (p = 0.011); the mean TG levels were 154.9 mg/dL (standard error [SE], 13.0), 177.0 mg/dL (SE, 12.1), 148.8 mg/dL (SE, 2.8), and 141.5 mg/dL (SE, 1.4) for 0 to 3, 4 to 7, 8 to 11, and ≥12 hours' fasting, respectively. In women, there was no difference in TG level according to fasting duration after adjustment for confounders. In men without diabetes, the TG level from 4 to 7 hours' fasting showed a significant difference between subjects with or without IHD/CVA even after adjustments for age, body mass index, lipid medication, exercise, and dietary factors (215.1 mg/dL vs. 177.3 mg/dL, p < 0.001).
CONCLUSIONS
In men, non-fasting TG levels from 4 to 7 hours' fasting were significantly associated with IHD/CVA, and were superior to fasting TG levels level in the significant association with the history of IHD or CVA.

Keyword

Non-fasting triglyceride; Cardiovascular disease; Myocardial ischemia; Fasting duration; Fasting triglyceride

MeSH Terms

Body Mass Index
Cardiovascular Diseases
Cerebrovascular Disorders*
Fasting
Female
Humans
Male
Meals
Myocardial Ischemia*
Stroke
Triglycerides*
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