Korean J Pediatr Infect Dis.  1997 Nov;4(2):232-239. 10.14776/kjpid.1997.4.2.232.

A Seroepidemiologic Study of Hepatitis A Virus in the Healthy Children and Adolescent in Kyonggi-do Province

• Roh HO
• Sohn YM
• Park MS
• Choi B
• Bang KN
• Ki M
• Kim JH

• KMID: 2440337
• DOI: http://doi.org/10.14776/kjpid.1997.4.2.232

Abstract

PURPOSE
The incidence of hepatitis A virus(HAV) infection has markedly decreased in the last 20 years due to industrialization and improvements in the standard of living and hygiene in Korea. The reduction in seroprevalence rates indicates infection potential for young adult population, and a need for vaccinations in high-risk adults and children groups has been suggested. In this study we evaluated the seroprevalence rates and natural infection rates of hepatitis A in children and adolescent to obtain the basic data for vaccination of hepatitis A.
METHODS
A total of 334 children and adolescent subjects below 20 years old in Kyonggi-do province were examined for HAV antibody and seroprevalence rates in each age group was investigated. In 584 elementary school students residing in Kyonggi-do province, serum samples collected in 1993 and 1996 from the same subjects for investigation of natural seroconversion rates. Method of testing antibody was enzyme immunoassay.
RESULTS
1) The seropositive rate of HAV in 334 subjects aged below 20 years old was 5.4%. According to age, the seropositive rates were 27.3% in infant group, 0.0% in 1~4 year-old group, 0.0% in 5~9 year-old group, 2.9% in 10~14 year-old group and 15.0% in 15~19 year-old group. 2) In the study of 584 elementary school children, only one subject showed seropositive in 1993, and in 1996 three different subjects showed seropositive results(0.5%); the natural seroconversion rate during 3 years was 0.5%. 3) The seroprevalence rates of below 20 year-old subjects reported in previous studios were 63.8% in 1979 and 47.3% in 1989 while the present study showed the rate at 5.4%.
CONCLUSION
Since natural antibody formation is rarely occurring, there is a high risk for apparent hepatitis A infection in adults. Therefore vaccination in high risk groups is essential at present, and in order to reduce the chance for hepatitis A infection in adults, vaccination in children may be needed.

Keyword

Hepatitis A; Seroprevalence rate; Vaccination

MeSH Terms

Adolescent*
Adult
Antibody Formation
Child*
Gyeonggi-do*
Hepatitis A virus*
Hepatitis A*
Hepatitis*
Humans
Hygiene
Immunoenzyme Techniques
Incidence
Infant
Korea
Methods
Only Child
Seroconversion
Seroepidemiologic Studies*
Socioeconomic Factors
Vaccination
Young Adult