Korean J Pediatr Infect Dis.  1998 Nov;5(2):302-307. 10.14776/kjpid.1998.5.2.302.

A Case of Cold Agglutinin Hemolytic Anemia Complicating Mycoplasma pneumoniae Pneumonia in Children

• Jo SO
• Park HJ

• KMID: 2440298
• DOI: http://doi.org/10.14776/kjpid.1998.5.2.302

Abstract

Hemolytic anemia doe to cold agglutinin disease is a known complication of Mycoplasma pneumoniae infection but is rarely observed, particularly in children. A case of Mycoplasma pneumonia complicated with hemolytic anemia is presented. 4 7 year-old girl was admitted because of fever, cough, sputum and pale appearance. Chest X-ray showed pneumonic consolidation of Rt. upper lobe, lingular division. Laboratory studies disclosed the following values : Hb 5.3g/dL, Hct 11.1%, reticulocyte 2.9%, indirect Coombs test negative, direct Coombs test(monovalent) Anti-C3d positive, Anti-IgG negative, Anti-IgM negative, cold agglutinin titer 1.256, mycoplasma antibody titer 1.640, total bilirubin 1.0mg/dL. Initial PBS before warming showed agglutination of red blood cells. The diagnosis of cold agglutinin hemolytic anemia complicating mycoplasma pneumonia was made. And treatment with roxithromycin, prednisolone and avoiding cold exposure was initiated, and complete recovery ensued. We report a case of cold agglutinin hemolytic anemia complicating mycoplasma pneumonia in children.

Keyword

Cold agglutinin hemolytic anemia; Mycoplasma pneumonia; Children

MeSH Terms

Agglutination
Anemia, Hemolytic*
Anemia, Hemolytic, Autoimmune
Bilirubin
Child*
Coombs Test
Cough
Diagnosis
Erythrocytes
Female
Fever
Humans
Mycoplasma pneumoniae*
Mycoplasma*
Pneumonia*
Pneumonia, Mycoplasma*
Prednisolone
Reticulocytes
Roxithromycin
Sputum
Thorax
Bilirubin
Prednisolone
Roxithromycin