Korean J Pediatr Infect Dis.  2003 May;10(1):123-126. 10.14776/kjpid.2003.10.1.123.

A Case of Subacute Necrotizing Lymphadenitis Associated with Yersinia Infection in a 12 Years Old Child

• Sim YH
• Lim IS
• Lee DK

• KMID: 2440107
• DOI: http://doi.org/10.14776/kjpid.2003.10.1.123

Abstract

Kikuchi disease(subacute necrotizing lymphadenitis), first reported by Kikuchi and Fujimoto in 1972, is a benign self-limiting illness characterized by fever, neutropenia and cervical lymphadenopathy and develops predominantly in young women, especially in Asia. The cause of Kikuchi disease is unknown, but postinfectious(virus or bacteria) hyperimmune reaction has been suggested. Few pediatric cases have been reported. We experienced a case of Kikuchi disease associated with Yersinia pseudotuberculosis infection in 12-year-old girl. After she was admitted with cervical lymphadenopathy and headache, followed by sustained fever with leukopenia. All symptoms and signs did not seem to be responded to antimicobial treatment. Open biopsy of cervical lymph node was performed and showed findings consistent with subacute necrotizing lymphadenitis. Serologic studies were all negative except for Y. pseudotuberculosis. Fever subsided and lymphadenopathy improved after administration of oral steroid for 1 week.

Keyword

Kikuchi disease; Subacute necrotizing lymphadenitis; Y. pseudotuberculosis

MeSH Terms

Asia
Biopsy
Child*
Female
Fever
Headache
Histiocytic Necrotizing Lymphadenitis
Humans
Leukopenia
Lymph Nodes
Lymphadenitis*
Lymphatic Diseases
Neutropenia
Yersinia Infections*
Yersinia pseudotuberculosis
Yersinia*