Korean J Pediatr Infect Dis.  2003 Nov;10(2):208-214. 10.14776/kjpid.2003.10.2.208.

Bacterial Meningitis in Children in One Tertiary Hospital

• Oh JE
• Chang JY
• Kwon YS
• Kim SK
• Son BK
• Hong YJ

• KMID: 2440089
• DOI: http://doi.org/10.14776/kjpid.2003.10.2.208

Abstract

PURPOSE
We performed a retrospective study on bacterial meningitis in children, pertaining to the causative organisms, bacterial resistance to antibiotics and the effect of recent introduction of Haemophilus influenzae type b(Hib) vaccine.
METHODS
We analysed the forty-three cases of bacterial meningitis which had been treated at the Inha University Hospital from June 1996 to June 2003.
RESULTS
Nineteen cases(44.2%) of them were infants younger than 2 months of age, and 29 cases(67.5%) younger than 1 year of age. The common causative organisms under 2 months of age were group B streptococcus(GBS)(47.4%), E. coli(21.1%), and Klebsiella pneumoniae( 21.1%). In the age group beyond 2 months of age, S. pneumoniae were seen in 50 %, H. influenzae in 16.7% and N. meningitidis in 16.7%. All of the five cases of Hib meningitis had not been vaccinated for Hib. There has been no Hib meningitis cases since 2001. Overall fatality rate was 4.5%, and complication occurred in 39%. Complications was significantly less frequent in patients resumed to be treated within 48 hours after onset compared to after 48 hours after onset. Penicillin resistance of S. pneumoniae and GBS isolated among bacterial meningitis cases was high.
CONCLUSION
Timing of treatment after the onset of the disease appeared the most important factor for prognosis of bacterial meningitis. The cases of H. influenzae meningitis have decreased probably due to Hib vaccination.

Keyword

Acute bacterial meningitis; Resistant pathogens; Hib meningitis

MeSH Terms

Anti-Bacterial Agents
Child*
Haemophilus influenzae
Haemophilus influenzae type b
Humans
Infant
Influenza, Human
Klebsiella
Meningitis
Meningitis, Bacterial*
Penicillin Resistance
Pneumonia
Prognosis
Retrospective Studies
Tertiary Care Centers*
Vaccination
Anti-Bacterial Agents