Korean J Pediatr Infect Dis.  2006 Nov;13(2):106-114. 10.14776/kjpid.2006.13.2.106.

Differences in T Serotypes and emm Genotypes of Group A Streptococci Obtained from Invasive and Non-invasive Streptococcal Infections

• Hahn W
• Kim S
• Ko H
• Jung S
• Cha S
• Lee H
• Lee K

• KMID: 2439977
• DOI: http://doi.org/10.14776/kjpid.2006.13.2.106

Abstract

PURPOSE
Studying the serotypes and emm genotype of group A streptococci(GAS) hold a key role in the investigation of epidemiology, pathogenesis, and resistance to antibiotics. We planed to find out the possible differences in serotypes and genotypes between the invasive and the non-invasive GAS infection.
METHODS
We obtained 39 isolates from the patients hospitalized in 2004 with the diagnosis of invasive GAS infectious diseases in the Severance Hospital, Yonsei University. We sent the isolates to the WHO Collaboratory Center in University of Minnesota and analyzed T serotypes and emm genotypes. These results were compared with non-invasive GAS infections in our hospital.
RESULTS
Compared this data with the results of 2003 to 2004, T2/28, T3, T5/27/44, T9 and NT were more prevalent. The NT showed statistically significant difference(P=0.019). The emm 3, emm 9, emm 18, emm 44 and emm provision type STG485 were more frequent genotypes compared with the study in 2003~2004, relatively. The emm provision type STG485 had statistically significant difference(P=0.000). The incidence of T12 plus T4, known as erythromycin(EM) resistant serotypes, was as low as 17.9% in this study, compared with those of non-invasive strains.
CONCLUSION
The incidence of EM-resistant strains is supposed not to be higher in invasive GAS infection. We could find out possible higher incidence of rheumatogenic strains in the invasive GAS infections. It seems to be important to have an effort on studying of serotyping and genotyping for the monitoring of strains and to know the epidemiologic characteristics.

Keyword

Group A streptococci; Serotype; Genotype; Erythromycin

MeSH Terms

Anti-Bacterial Agents
Communicable Diseases
Diagnosis
Epidemiology
Erythromycin
Genotype*
Humans
Incidence
Minnesota
Serogroup*
Serotyping
Streptococcal Infections*
Anti-Bacterial Agents
Erythromycin