Korean J Gastroenterol.  2005 Feb;45(2):111-117.

Trial of Moxifloxacin-containing Triple Therapy after Initial and Second-line Treatment Failures for Helicobacter pylori Infection

• Cheon JH
• Kim N
• Lee DH
• Kim JW
• Hwang JH
• Park YS
• Kim JM
• Suh SO
• Jung HC
• Song IS

Abstract

BACKGROUND/AIMS: Proton-pump inhibitor (PPI)-based triple therapy for Helicobacter pylori eradication is widely used with considerable failure rate. Bismuth-based, second-line therapy is also associated with failures in more than 20% of cases in Korea. Our aim was to evaluate the efficacy and tolerability of third-line therapy containing moxifloxacin as a rescue in Korea. METHODS: The subjects consisted of 201 patients infected with H. pylori, who were treated with PPI-based therapy, 42 patients treated with bismuth-based after failure of initial PPI triple therapy, and 10 patients treated with moxifloxacin-containing triple therapy after failure of successive initial and second-line therapy. Eradication rate, compliance and side effect rates were compared. RESULTS: The eradication rates of initial, second-line, and third-line therapy were as follows: 67.2%/83.3%, 54.8%/76.7%, 80.0%/88.9% by intention-to-treat and per protocol analysis, respectively. The compliance of patients for each treatment was 98.2%, 90.9%, 100%, respectively. The side effect rate was significantly higher in the bismuth triple therapy than in the PPI- or moxifloxacin-containing triple therapy (p<0.05). CONCLUSIONS: Moxifloxacin-containing triple therapy shows high eradication rate with fewer side effects and good compliance. Thus, this regimen could be used as a rescue therapy.

Keyword

Helicobacter pylori; Second-line therapy; Rescue therapy; Moxifloxacin

MeSH Terms

Adult
Aged
Antacids/administration & dosage
Anti-Bacterial Agents/administration & dosage
Aza Compounds/*administration & dosage
Bismuth/administration & dosage
Drug Therapy, Combination
Female
Helicobacter Infections/*drug therapy
*Helicobacter pylori
Humans
Male
Middle Aged
Proton Pumps/antagonists & inhibitors
Quinolines/*administration & dosage