Genomics Inform.
2018 Dec;16(4):e21. 10.5808/GI.2018.16.4.e21.
An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
- Affiliations
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- 1Department of Biomedical Veterinary Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA. soojin.jeon@liu.edu
- 2Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
- 3D. H. Barron Reproductive and Perinatal Biology Research Program, University of Florida, Gainesville, FL 32610, USA.
- KMID: 2439211
- DOI: http://doi.org/10.5808/GI.2018.16.4.e21
Abstract
- Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial and ovarian function are not fully recovered, which results in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Recent studies using high-throughput sequencing observed very low relative abundance of Escherichia coli, Trueperella pyogenes, and Prevotella melaninogenica in cows with metritis. Herein, we propose that metritis is associated with a dysbiosis of the uterine microbiota, which is characterized by high abundance of Bacteroides, Porphyromonas, and Fusobacterium.
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