Ann Geriatr Med Res.
2018 Dec;22(4):176-183. 10.4235/agmr.18.0032.
Associations of Elderly Onset Headache With Occurrence of Poor Functional Outcome, Cardiovascular Disease, and Cognitive Dysfunction During Longterm Follow-up
- Affiliations
-
- 1Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
- 2Department of Neurology, Eulji University School of Medicine, Seoul, Korea.
- 3Department of Neurology, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
- 4Department of Neurology, Chungnam National University College of Medicine, Daejeon, Korea.
- 5Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea.
- 6Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 7Department of Neurology, National Police Hospital, Seoul, Korea.
- 8Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
- 9Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
- 10Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- 11Department of Neurology, Ewha Womans University College of Medicine, Seoul, Korea. knstar@ewha.ac.kr
- KMID: 2439113
- DOI: http://doi.org/10.4235/agmr.18.0032
Abstract
- BACKGROUND
Although the frequency and intensity of headaches decrease in older adults, headaches in this population are still an important neurological disorder. The purpose of this study was to investigate the associations of headache characteristics in older adults with the development of cardiovascular disease and cognitive dysfunction.
METHODS
We prospectively enrolled 125 older (≥ 65 years old) patients with headache who were making their first visit to outpatient clinics and who had no prior history of cognitive dysfunction from 11 hospitals in Korea between August 2014 and February 2015. We investigated the occurrence of newly developed/or recurrent headache, cardiovascular disease, cognitive dysfunction, and poor functional outcomes.
RESULTS
The mean age of all included patients was 72.6 years, 68.8% were women, and 43 (34.4%) had newly developed/or recurrent headache during follow-up. During a median follow-up of 31 months (interquartile range, 28-34 months), 21 participants (16.8%) experienced cardiovascular disease, and 26 (20.8%) developed cognitive dysfunction. Upon multivariate analysis and after adjusting for sex, age, and other factors, presence of newly developed/or recurrent headache was found to be associated with cardiovascular disease (hazard ratio [HR], 4.03; 95% confidence interval [CI], 1.28-12.61; p=0.017) and frequency of headache for the recent 3 months was related with cognitive dysfunction (HR, 1.05; 95% CI, 1.00-1.09; p=0.017) and poor functional outcomes (HR, 1.06; 95% CI, 1.01-1.11; p=0.011).
CONCLUSION
Our study demonstrated that there is an increased risk of cardiovascular disease, cognitive dysfunction, and poor functional outcomes in older patients with frequent, newly developed, or recurrent headache.
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