Ann Dermatol.  2019 Apr;31(2):209-212. 10.5021/ad.2019.31.2.209.

Symmetrical Giant Facial Plaque-Type Juvenile Xanthogranuloma: A Case Report with a Successful Response to Fractional COâ‚‚ Laser Treatment

• Lee YI
• Oh SH

• KMID: 2439068
• DOI: http://doi.org/10.5021/ad.2019.31.2.209

Abstract

Symmetrical giant facial plaque-type juvenile xanthogranuloma (SGFP-JXG) is a rare variant of juvenile xanthogranuloma, reported only in two cases in the literature. We report a case of a 3-year-old Korean boy who developed bilateral yellowish indurated plaques on both cheeks since 1 year after birth. A skin biopsy revealed numerous foam cells and Touton type giant cells throughout the upper dermis, and its immunohistochemical studies resulted positive for CD68 and negative for S-100. The boy was therefore diagnosed as a persistent SGFP-JXG. As the lesion did not show any signs of spontaneous regression, we performed a single session of fractional ablative COâ‚‚ laser, which resulted in a significant reduction of the lesion. This is the first case report of a persistent SGFP-JXG on which a single ablative laser therapy was performed with a successful outcome.

Keyword

Histiocytosis; Juvenile xanthogranuloma; Laser therpy; Xanthomatosis

MeSH Terms

Biopsy
Cheek
Child, Preschool
Dermis
Foam Cells
Giant Cells
Histiocytosis
Humans
Laser Therapy
Male
Parturition
Skin
Xanthogranuloma, Juvenile*
Xanthomatosis

Figure

• 

  Fig. 1 We received the patient's consent form for publishing all photographic materials. (A) Initial photography of the bilateral symmetric yellowish plaques distributed on both cheeks. (B) Six-month follow-up photography after a single session of fractional ablative CO2 laser, showing reduced sizes of the lesions.

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  Fig. 2 (A, B) Haematoxylin-eosin staining of the yellowish plaque on the right cheek. Numerous foam cells and Touton giant cells with occasional foreign body giant cells are seen as indicated by arrows. (C) Immunohistochemical staining of the lesion showing CD68 positive histiocytes. (D) Immunohistochemical staining of the lesion showing a negative staining result on S-100 (×20).

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