J Korean Ophthalmol Soc.  2008 Jul;49(7):1173-1176. 10.3341/jkos.2008.49.7.1173.

Juvenile Xanthogranuloma Presenting as a Nodule of the Eyelid

• Lee KM
• Kim NJ

• KMID: 1476974
• DOI: http://doi.org/10.3341/jkos.2008.49.7.1173

Abstract

PURPOSE
To report one case of juvenile xanthogranuloma presenting as a unilateral nodule of the eyelid.
CASE SUMMARY
A 4-year-old girl presented with a solitary eyelid nodule. There were no other ophthalmologic problems. Excisional biopsy and simple wound closure were performed. A biopsy showed intense infiltration of histiocytes, lymphocytes, and multinucleated giant cells in the dermis, which was compatible with juvenile xanthograunuloma.
CONCLUSION
Juvenile xanthogranuloma should be considered in the differential diagnosis of a solitary eyelid tumor.

Keyword

Eyelid tumor; Histiocytosis; Juvenile xanthogranuloma

MeSH Terms

Biopsy
Dermis
Diagnosis, Differential
Eyelids
Giant Cells
Histiocytes
Histiocytosis
Lymphocytes
Preschool Child
Xanthogranuloma, Juvenile

Figure

• 

  Figure 1. Photographs of the patient’s eyelid: (A, B) Note a relatively large (7×5×4 mm) reddish yellow pedunculated solitary nodule in the canthal area.

• 

  Figure 2. Light micrographs of excised mass. (A) hematoxylin and eosin-stained section showed intense infiltration of histiocytes, lymphocytes, and multinucleated giant cells in the dermis (H&E, ×100). (B) a multinucleated giant cell (arrow) (H&E, ×400).

Reference

References

1. Park SH, Rah SH, Kim YH. Juvenile xanthogranuloma as an isolated corneoscleral limbal mass: a case report. Korean J Opthalmol. 2003; 17:63–6.

2. Adamson HG. A case of congenital xanthoma multiplex. Society intelligence, The Dermatological Society of London. Br J Dermatol. 1905; 17:222.

3. Mc Donagh JE. A contribution to our knowledge of the naevoxantho-endotheliomata. Br J Dermatol. 1912; 24:85–99.

4. Helwig EB, Hackney VC. Juvenile xanthogranuloma (nevoxanthoendothelioma). Am J Pathol. 1954; 30:625–6.

5. Parmley VC, George DP, Fannin LA. Juvenile xanthogranul oma of the iris in an adult. Arch Ophthalmol. 1998; 116:377–9.

6. Zimmerman LE. Ocular lesions of juvenile xanthogranulmoa. Nevoxanthoendothelioma. Trans Am Acad Ophthalmol Otolaryngol. 1965; 69:412–42.

7. Zimmerman LE. Ocular lesions of juvenile xanthogranuloma. Nevoxanthoendothelioma. Am J Ophthalmol. 1965; 60:1011–35.

8. Blank H, Eglick PG, Beerman H. Nevoxantho-endothelioma with ocular involvement. Pediatrics. 1949; 4:349–54.

9. Newell GB, Stone OJ, Mulllins JF. Juvenile xanthogranuloma and neurofibromatosis. Arch Dermatol. 1973; 107:262.

10. Sibulkin D, Olichney JJ. Juvenile xanthogranuloma in a patient with Niemann-Pick disease. Arch Dermatol. 1973; 108:829–31.

11. De Villez RL, Limmer BL. Juvenile xanthogranuloma and urticaria pigmentosa. Arch Dermatol. 1975; 111:365–6.

12. Cooper PH, Frierson HF, Kayne AL, Sabio H. Association of juvenile xanthogranuloma with juvenile myeloid leukemia. Arch Dermatol. 1984; 120:371–5.

13. Zelger BG, Zelger B, Steiner H, Mikuz G. Solitary giant xanthogranuloma and benign cephalic histiocytosis-variants of juvenile xanthogranuloma. Br J Dermatol. 1995; 135:598–604.

14. Sonoda T, Hashimoto H, Enjoji M. Juvenile xanthogranuloma: clinicopathologic analysis and immunohistochemical study of 57 patients. Cancer. 1985; 56:2280–6.

15. Miller RL, Sheeler LR, Bauer TW, Bukowski RM. Erdheim Chester disease. Case report and review of literature. Am J Med. 1986; 80:1230–6.

16. Mehregan DA. Winkelmann. Necrobiotic xanthogranuloma. Arch Dermatol. 1992; 128:94–100.

17. Hayashi N, Komatsu T, Kotmasu T. . Juvenile xantho granuloma presenting with unilateral prominent nodule of the eyelid: report of a case and clinicopathologic findings. Jpn J Ophthalmol. 2004; 48:435–9.