Ann Hepatobiliary Pancreat Surg.  2019 Feb;23(1):34-40. 10.14701/ahbps.2019.23.1.34.

Gangrenous cholecystitis in male patients: A study of prevalence and predictive risk factors

• Gomes CA
• Soares C
• Di Saverio S
• Sartelli M
• de Souza Silva PG
• Orlandi AS
• Heringer T
• Gomes FC
• Catena F

• KMID: 2439043
• DOI: http://doi.org/10.14701/ahbps.2019.23.1.34

Abstract

BACKGROUNDS/AIMS
The prevalence and risk factors of gangrenous cholecystitis in male are unknown.
OBJECTIVE
To verify the prevalence and risk factors of gangrenous cholecystitis in males.
METHODS
This cross-sectional study includes 95 patients (59.5±17.1 years), with clinical and histopathological diagnosis, operated laparoscopically on 2012-2016. Eligibility was decided based on the variables of age; tachycardia (>100 bpm); leukocytosis (>10,000/mm³); Murphy's sign; gallbladder wall thickness (>4 mm); biochemical tests, morbidities (diabetes, alcoholism, smoking) and mortality. Multivariate regression, the chi-squared and Prevalent Chances Ratio (PCR) were used to define a few parameters.
RESULTS
The prevalence of gangrenous cholecystitis in men older than 50 years was 29.3%. The risk factors for the disease were as follows: diabetes mellitus (p=0.006, RCP=4.191), leukocytosis (p=0.003), gallbladder thickness greater than 4 mm (p=0.035, RCP=3.818), which increased mortality [(p=0.04) (RCP=8.001)]. Murphy's sign showed a negative association (p=0.002, RCP=0.204). Values close to significance were observed in relation to gamma glutamyl transferase (p=0.083, RCP=3.125) and hospital stay (p=0.061, RCP=2.765).
CONCLUSIONS
Male gender, and age older than 50 years, were correlated with a high prevalence of necrosis, higher than that reported in females. The risk factors for developing necrosis are the same as those described for female patients.

Keyword

Abdominal infections; Abdominal surgery; Cholecystectomy; Complication; Laparoscopic surgery

MeSH Terms

Alcoholism
Cholecystectomy
Cholecystitis*
Cross-Sectional Studies
Diabetes Mellitus
Diagnosis
Female
Gallbladder
Humans
Laparoscopy
Length of Stay
Leukocytosis
Male*
Mortality
Necrosis
Prevalence*
Risk Factors*
Tachycardia
Transferases
Transferases

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