Exp Neurobiol.  2019 Feb;28(1):43-53. 10.5607/en.2019.28.1.43.

14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors

• Kim DE
• Cho CH
• Sim KM
• Kwon O
• Hwang EM
• Kim HW
• Park JY

• KMID: 2439005
• DOI: http://doi.org/10.5607/en.2019.28.1.43

Abstract

14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.

Keyword

14-3-3γ; Ywhag; Hyperactivity; Anxiety; Acute stress; ADHD

MeSH Terms

Animals
Anxiety
Brain
Heterozygote
Mice*
Mice, Knockout
Williams Syndrome