Exp Neurobiol.  2019 Feb;28(1):43-53. 10.5607/en.2019.28.1.43.

14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors

Affiliations
  • 1College of Life Sciences, Sejong University, Seoul 05006, Korea. kimhyung@sejong.ac.kr
  • 2School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 02708, Korea. jaeyong68@korea.ac.kr
  • 3Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

Abstract

14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.

Keyword

14-3-3γ; Ywhag; Hyperactivity; Anxiety; Acute stress; ADHD

MeSH Terms

Animals
Anxiety
Brain
Heterozygote
Mice*
Mice, Knockout
Williams Syndrome
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