J Breast Cancer.  2017 Sep;20(3):264-269. 10.4048/jbc.2017.20.3.264.

Clinicopathologic Characteristics of Pregnancy-Associated Breast Cancer: Results of Analysis of a Nationwide Breast Cancer Registry Database

• Kim YG
• Jeon YW
• Ko BK
• Sohn G
• Kim EK
• Moon BI
• Youn HJ
• Kim HA
• Korean Breast Cancer Society

• KMID: 2438993
• DOI: http://doi.org/10.4048/jbc.2017.20.3.264

Abstract

PURPOSE
This study aimed to evaluate the clinicopathological characteristics of pregnancy-associated breast cancer (PABC) in comparison with non-pregnancy associated breast cancer (non-PABC).
METHODS
A total of 344 eligible patients with PABC were identified in the Korean Breast Cancer Society Registry database. PABC was defined as ductal carcinoma in situ, invasive ductal carcinoma, or invasive lobular carcinoma diagnosed during pregnancy or within 1 year after the birth of a child. Patients with non-PABC were selected from the same database using a 1:2 matching method. The matching variables were operation, age, and initial stage.
RESULTS
Patients with PABC had significantly lower survival rates than patient with non-PABC (10-year survival rate: PABC, 76.4%; non-PABC, 85.1%; p=0.011). PABC patients had higher histologic grade and were more frequently hormone receptor negative than non-PABC patients. Being overweight (body mass index [BMI], ≥23 kg/m²), early menarche (≤13 years), late age at first childbirth (≥30 years), and a family history of breast cancer were more common in the PABC group than in the non-PABC group. Multivariate analysis showed the following factors to be significantly associated with PABC (vs. non-PABC): early menarche (odds ratio [OR], 2.165; 95% confidence interval [CI], 1.566-2.994; p<0.001), late age at first childbirth (OR, 2.446; 95% CI, 1.722-3.473; p<0.001), and being overweight (OR, 1.389; 95% CI, 1.007-1.917; p=0.045).
CONCLUSION
Early menarche, late age at first childbirth, and BMI ≥23 kg/m² were more associated with PABC than non-PABC.

Keyword

Breast neoplasms; Pregnancy; Survival

MeSH Terms

Breast Neoplasms*
Breast*
Carcinoma, Ductal
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Lobular
Child
Female
Humans
Menarche
Methods
Multivariate Analysis
Overweight
Parturition
Pregnancy
Survival Rate

Figure

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  Figure 1 Flow chart of patient selection.KBCR=Korean Breast Cancer Society Registry; IDC=invasive ductal carcinoma; ILC=invasive lobular carcinoma; DCIS=ductal carcinoma in situ; PABC=pregnancy-associated breast cancer.

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  Figure 2 Kaplan-Meier analysis of overall survival rates for pregnancy-associated breast cancer (PABC) patients and non-PABC patients (10-year overall survival rate: PABC, 76.4%; non-PABC, 85.1%; p=0.011).

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