J Stroke.
2019 Jan;21(1):23-30. 10.5853/jos.2018.03097.
Patent Foramen Ovale: Story Closed?
- Affiliations
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- 1Department of Neurology, Essen University Hospital, Essen, Germany. Martin.koehrmann@uk-essen.de
- 2Johannes Wesling Medical Center Minden, UK RUB, Minden, Germany.
- 3Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
- 4Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
- 5Department of Neurology, Frankfurt Hoechst Hospital, Frankfurt, Germany.
- 6Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
- KMID: 2438647
- DOI: http://doi.org/10.5853/jos.2018.03097
Abstract
- The optimal treatment strategy for secondary prevention in patients with cryptogenic stroke and patent foramen ovale (PFO) has been a matter of controversy for decades. After three randomized trials failed to show a benefit of closure with an excess of complications in the interventional arm, two large recent trials suggest a benefit with regard of preventing further ischemic strokes. With this discrepancy in results it is important to discuss recent trials in detail and evolve an informed clinical approach for daily practice.
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