Neonatal Med.  2018 May;25(2):85-89. 10.5385/nm.2018.25.2.85.

Neonatal Seizures with Diffuse Cerebral White Matter Lesions on Magnetic Resonance Imaging Associated with Rotavirus Infection: A Report of Three Cases

• Choi MS
• Park SK
• Lee JH

• KMID: 2437903
• DOI: http://doi.org/10.5385/nm.2018.25.2.85

Abstract

Rotavirus is the major cause of gastroenteritis in children under the age of 5. Rotavirus infection may lead to several neurological complications as meningitis, encephalitis, convulsion, encephalopathy, hemorrhagic shock, central pontine myelinolysis, Guillain-Barre syndrome, and Reye's syndrome. Further, some reports have described diffuse cerebral white matter lesions on diffusion-weighted magnetic resonance imaging (MRI) in neonates with rotavirus induced seizures. Here, we report on three neonates with rotavirus induced seizures with cerebral white matter abnormalities on MRI.

Keyword

Newborn; Seizure; Diffusion magnetic resonance imaging; Rotavirus

MeSH Terms

Brain Diseases
Child
Diffusion Magnetic Resonance Imaging
Encephalitis
Gastroenteritis
Guillain-Barre Syndrome
Humans
Infant, Newborn
Magnetic Resonance Imaging*
Meningitis
Myelinolysis, Central Pontine
Reye Syndrome
Rotavirus Infections*
Rotavirus*
Seizures*
Shock, Hemorrhagic
White Matter*

Figure

• 

  Figure 1. Diffusion-weighted brain magnetic resonance imagings of the three patients after seizure onset (A, patient 1; B, patient 2; C, patient 3) show diffuse high signal intensities (arrows) with diffusion restriction in both periventricular white matter of lateral ventricles.

• 

  Figure 2. Brain magnetic resonance imagings of the three patients at one month after onset of patients (A, patient 1; B, patient 2; C, patient 3) show cystic periventricular leukomalacia (arrows) in both frontal lobes.

• 

  Figure 3. Brain magnetic resonance imaging of patient 1 at 1 year after onset shows high signal intensity lesions (arrows) at the periventricular area in both frontal lobes.

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