Osteoporos Sarcopenia.  2018 Mar;4(1):11-15. 10.1016/j.afos.2018.03.002.

Romosozumab for the treatment of osteoporosis

• McClung MR

• KMID: 2437854
• DOI: http://doi.org/10.1016/j.afos.2018.03.002

Abstract

Romosozumab, a specific inhibitor of sclerostin, is a unique approach to therapy for postmenopausal osteoporosis and related disorders. The elucidation of sclerostin deficiency as the molecular defect of syndromes of high bone mass with normal quality, and the pivotal role of sclerostin as a mediator of osteoblastic activity and bone formation, provided the platform for the evaluation of inhibitors of sclerostin to activate bone formation. An extensive preclinical program and 2 large fracture endpoint trials with romosozumab, a sclerostin-binding antibody, have been completed. This review will highlight the results of those studies and describe the current status of romosozumab as a potential therapy for osteoporosis.

Keyword

Romosozumab; Sclerostin; Osteoporosis; Fracture risk; Manuscript category

MeSH Terms

Female
Humans
Osteoblasts
Osteogenesis
Osteoporosis*
Osteoporosis, Postmenopausal