Keimyung Med J.  2018 Jun;37(1):1-8. 10.0000/kmj.2018.37.1.1.

Incidence and Associated Factor of Adverse Events of Tigecycline Therapy in Korean Patients

• So IT
• Lee JY
• Hyun M
• Kim HA
• Ryu SY

• KMID: 2437654
• DOI: http://doi.org/10.0000/kmj.2018.37.1.1

Abstract

Tigecycline is a broad spectrum antibiotic which has been used for complicated intra-abdominal infection and complicated skin and soft tissue infection by multi-drug resistant bacteria. However recent meta-analysis studies have raised a concern for adverse events of tigecycline. We analyzed retrospectively adverse events, associated factors of adverse events in multi-drug resistant bacteria caused infections treated with tigecycline in Korean patients. One hundred-sixty patients treated with tigecycline from July 2009 to September 2013 were enrolled in this study. Their clinical and microbiologic data were reviewed. History of invasive procedure within 7 days and recent operation within 3 months were associated with adverse events. The most common adverse events were nausea and vomiting. Associated factors of nausea were soft tissue injury and recent operation within 3 months. In this study, nausea was the most common adverse event in patients who received tigecycline. Although it is not serious complication, monitoring of adverse events is required to increase compliance.

Keyword

Adverse drug reaction; Multiple-drug resistance; Tigecycline

MeSH Terms

Bacteria
Compliance
Drug-Related Side Effects and Adverse Reactions
Humans
Incidence*
Intraabdominal Infections
Nausea
Retrospective Studies
Skin
Soft Tissue Infections
Soft Tissue Injuries
Vomiting