J Korean Child Neurol Soc.  2018 Dec;26(4):215-220. 10.26815/jkcns.2018.26.4.215.

The Prognostic Factors Affecting the Occurrence of Subsequent Unprovoked Seizure in Patients Who Present with Febrile Seizure after 6 Years of Age

• Lee HJ
• Kim SH

• KMID: 2437103
• DOI: http://doi.org/10.26815/jkcns.2018.26.4.215

Abstract

PURPOSE
Few reports have described the prognostic factors affecting the occurrence of subsequent unprovoked seizure in patients who present with febrile seizure (FS) after 6 years of age. We investigated the prognostic factors affecting the development of unprovoked seizures after FS among patients from Jeju Island.
METHODS
We included patients who developed FS after 6 years of age, who presented to our outpatient clinic between January, 2011 and June, 2017. Clinical data were obtained through chart reviews and phone call interviews. We used logistic regression analysis to analyze the risk factors associated with the occurrence of subsequent unprovoked seizure.
RESULTS
Of the 895 patients who presented to our hospital due to their febrile seizure, 83 developed FS after 6 years of age. Among them, 3 patients were prescribed antiepileptic drugs before the onset of the unprovoked seizure, and 4 patients developed an unprovoked seizure before 6 years of age. Thus, overall, 76 patients were included in the study. 51 patients developed first FS before 6 years of age. In the remaining patients, the first FS developed after 6 years of age. The mean observational period since the last outpatient follow-up visit was 3.2 years (median 3.04 years, range: 1.42-4.71 years). Among them, 21% developed an unprovoked seizure. Logistic regression analysis showed that electroencephalographic (EEG) abnormalities served as an independent risk factor for a subsequent unprovoked seizure.
CONCLUSION
EEG is the proper diagnostic tool to predict the risk of a subsequent unprovoked seizure in patients with FS after 6 years of age.

Keyword

Febrile seizure; Unprovoked seizure

MeSH Terms

Ambulatory Care Facilities
Anticonvulsants
Electroencephalography
Follow-Up Studies
Humans
Logistic Models
Outpatients
Risk Factors
Seizures*
Seizures, Febrile*
Anticonvulsants