Korean J Otorhinolaryngol-Head Neck Surg.  2018 Oct;61(10):536-540. 10.3342/kjorl-hns.2017.00073.

Various Clinical Presentation of Post-Transplant Lymphoproliferative Disorder in Head and Neck: A Case Series of 3 Patients

• Kim HJ
• Choi SJ
• Ko YH
• Choi N

• KMID: 2436545
• DOI: http://doi.org/10.3342/kjorl-hns.2017.00073

Abstract

The outcome of solid organ and bone marrow transplantation has been dramatically improved with the development of immunosuppressive agent. However, the use of immunosuppressive agents could increase the risk of malignancies such as post-transplant lymphoproliferative disorder (PTLD). PTLD is regarded as the lymphoid malignancy of patients using immunosuppressive agents, and it could present diverse and non-specific symptoms. It involves various organs including the tonsil, adenoid, lymph node, and the brain. Because of its poor prognosis, an early suspicion of pathologic diagnosis is crucial for the treatment of PTLD. In this report, we demonstrate the case of three pediatric patients who had been treated for PTLD of various clinical presentations by early suspicion and pathologic diagnosis.

Keyword

Head and neck; Immunosuppressive agent; Post-transplant lymphoproliferative disorder

MeSH Terms

Adenoids
Bone Marrow Transplantation
Brain
Diagnosis
Head*
Humans
Immunosuppressive Agents
Lymph Nodes
Lymphoproliferative Disorders*
Neck*
Palatine Tonsil
Prognosis
Immunosuppressive Agents