Anesth Pain Med.  2018 Jul;13(3):286-291. 10.17085/apm.2018.13.3.286.

Nefopam does not influence onset and recovery profiles of rocuronium-induced neuromuscular block: a prospective, double-blinded, randomized, controlled study

• So KY
• Moon HM
• Kim SH

• KMID: 2436036
• DOI: http://doi.org/10.17085/apm.2018.13.3.286

Abstract

BACKGROUND
We investigated the hypothesis that pretreatment with nefopam 20 mg would influence the onset and recovery profiles of rocuronium-induced neuromuscular block.
METHODS
After Institutional Review Board approval, 134 patients, aged between 20-65 years, belonging to the American Society of Anesthesiologists physical status classification I or II, were randomly allocated to receive either 0.9% normal saline (control group) or nefopam 20 mg (nefopam group), infused over one hour before induction of anesthesia. Anesthesia was induced with remifentanil and propofol, followed by endotracheal intubation with rocuronium 0.6 mg/kg. We recorded the lag time, onset time, clinical duration, recovery index, recovery time, and total recovery time.
RESULTS
We included 111 patients in the final analysis. The lag time, onset time, clinical duration, recovery index, recovery time, and total recovery time of the nefopam group (n = 57) were not significantly different compared with that of the control group (n = 54).
CONCLUSIONS
Pretreatment with nefopam 20 mg one hour before induction of anesthesia does not have a significant influence on the onset and recovery profiles of rocuronium-induced neuromuscular block.

Keyword

Drug interactions; Nefopam; Neuromuscular monitoring; Neuromuscular nondepolarizing agents

MeSH Terms

Anesthesia
Classification
Drug Interactions
Ethics Committees, Research
Humans
Intubation, Intratracheal
Nefopam*
Neuromuscular Blockade*
Neuromuscular Monitoring
Neuromuscular Nondepolarizing Agents
Propofol
Prospective Studies*
Nefopam
Neuromuscular Nondepolarizing Agents
Propofol

Figure

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  Fig. 1 CONSORT diagram. 0.9% sodium chloride solution (control group) or nefopam 20 mg (2 ml) in 0.9% sodium chloride solution 100 ml (nefopam group) is infused one hour before surgery at a rate of 100 ml/h. CONSORT: consolidated standards of reporting trials.

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