Child Kidney Dis.
2018 Oct;22(2):81-85. 10.3339/jkspn.2018.22.2.81.
A Pediatric Case of Inflammatory Bowel Disease with Renal Amyloidosis
- Affiliations
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- 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea. Cheonghi@snu.ac.kr
- 2Department of Pathology, Seoul National University Hospital, Seoul, Korea.
- 3Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2435376
- DOI: http://doi.org/10.3339/jkspn.2018.22.2.81
Abstract
- Amyloidosis is a rare disease that results from the deposition of extracellular protein in various body tissues, causing progressive organ dysfunction. Secondary renal amyloidosis is a rare but serious complication of chronic inflammatory bowel disease, particularly in patients with Crohn's disease or ulcerative colitis. We report a case of secondary renal amyloidosis in a pediatric patient who reported a 16-year history of "very early onset inflammatory bowel disease". Intensive treatment including repeated infliximab infusions improved clinical parameters of inflammatory bowel disease, although renal dysfunction showed progression. Amyloidosis should be considered in patients with IBD, particularly if they suffered disease progression.
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